hrcak mascot   Srce   HID

Sažetak sa skupa

BPC 157 given during reperfusion counteracts portal hypertension, caval hypertension, and aortal hypotension in rats with prior portal triad obstruction

Emma Orešković ; School of Medicine University of Zagreb
Helena Žižek ; School of Medicine University of Zagreb
Marina Madunić ; School of Medicine University of Zagreb
Will Migo ; School of Medicine University of Zagreb
Marko Belamarić ; School of Medicine University of Zagreb
Hrvoje Vraneš ; School of Medicine University of Zagreb
Slaven Gojković ; School of Medicine University of Zagreb

Puni tekst: engleski, pdf (67 KB) str. 0-0 preuzimanja: 7* citiraj
APA 6th Edition
Orešković, E., Žižek, H., Madunić, M., Migo, W., Belamarić, M., Vraneš, H. i Gojković, S. (2019). BPC 157 given during reperfusion counteracts portal hypertension, caval hypertension, and aortal hypotension in rats with prior portal triad obstruction. Liječnički vjesnik, 141 (suppl.1), 0-0. Preuzeto s https://hrcak.srce.hr/221484
MLA 8th Edition
Orešković, Emma, et al. "BPC 157 given during reperfusion counteracts portal hypertension, caval hypertension, and aortal hypotension in rats with prior portal triad obstruction." Liječnički vjesnik, vol. 141, br. suppl.1, 2019, str. 0-0. https://hrcak.srce.hr/221484. Citirano 06.12.2019.
Chicago 17th Edition
Orešković, Emma, Helena Žižek, Marina Madunić, Will Migo, Marko Belamarić, Hrvoje Vraneš i Slaven Gojković. "BPC 157 given during reperfusion counteracts portal hypertension, caval hypertension, and aortal hypotension in rats with prior portal triad obstruction." Liječnički vjesnik 141, br. suppl.1 (2019): 0-0. https://hrcak.srce.hr/221484
Harvard
Orešković, E., et al. (2019). 'BPC 157 given during reperfusion counteracts portal hypertension, caval hypertension, and aortal hypotension in rats with prior portal triad obstruction', Liječnički vjesnik, 141(suppl.1), str. 0-0. Preuzeto s: https://hrcak.srce.hr/221484 (Datum pristupa: 06.12.2019.)
Vancouver
Orešković E, Žižek H, Madunić M, Migo W, Belamarić M, Vraneš H i sur. BPC 157 given during reperfusion counteracts portal hypertension, caval hypertension, and aortal hypotension in rats with prior portal triad obstruction. Liječnički vjesnik [Internet]. 2019 [pristupljeno 06.12.2019.];141(suppl.1):0-0. Dostupno na: https://hrcak.srce.hr/221484
IEEE
E. Orešković, et al., "BPC 157 given during reperfusion counteracts portal hypertension, caval hypertension, and aortal hypotension in rats with prior portal triad obstruction", Liječnički vjesnik, vol.141, br. suppl.1, str. 0-0, 2019. [Online]. Dostupno na: https://hrcak.srce.hr/221484. [Citirano: 06.12.2019.]

Sažetak
Reperfusion provokes major disturbances after the Pringle maneuver. We demonstrated the usefulness of the stable gastric pentadecapeptide BPC 157 as therapy for the hemodynamic disturbances after the Pringle maneuver, a temporary portal triad obstruction (PTO) (hepatic artery, portal vein, common bile duct occlusion for 30 min), with BPC 157 given during reperfusion, in the post-PTO period. In deeply anesthetized and laparatomized rats that had a PTO, the recording lasted 5 minutes with a cannula connected to a pressure transducer, inserted into the portal vein, inferior caval vein and abdominal aorta at the level of its bifurcation at 24 h of reperfusion time. BPC 157 or saline was applied as an abdominal bath in rats that had a PTO, in the post-PTO-period, at 1 min or at 24 h reperfusion time. When BPC 157 was given in circumstances of portal and caval hypertension, and arterial hypotension, disturbances were completely eliminated. This presents a potential therapeutic advantage. Thereby, whithout therapy, the pressure of both the portal and the caval system remains elevated after removal of the portal clamp. Thus, the effectiveness of the therapy, when given at distinctive points during reperfusion, appears as conclusive evidence of its efficacy. BPC 157 therapy mitigates the whole syndrome, involving the course of an even more complex model that should include rats clamped by the hepatic artery, portal vein, and bile duct vs. rats that used to have a clamped portal triad and later underwent reperfusion.

Ključne riječi
BPC-157, Reperfusion, Portal Triad Obstruction

Hrčak ID: 221484

URI
https://hrcak.srce.hr/221484

Posjeta: 26 *