Veterinarska stanica, Vol. 48 No. 6, 2017.
Pregledni rad
Residues of coccidiostats in products of animal origin after administration in poultry
Ivana Varenina
Nina Bilandžić
Đurđica Božić Luburić
Božica Solomun Kolanović
Ines Varga
Relja Beck
Sažetak
Antimicrobial agents are widely applied in human and veterinary medicine, including antibacterial, antifungal, antiviral and antiparasitic drugs. Few of these substances are approved for use in prophylaxis during intensive breeding of animals whose products are targeted for the market. Despite this, veterinary drug residues are often present in food of animal origin. Coccidiostats are also classified into this group of drugs that are highly present in poultry-farming for prophylaxis and therapy. Coccidiosis is a parasitic disease caused by the unicellular protozoon of the genus Eimeria. Due to its great reproductive potential, survival of sporulated oocysts in soil and various pathogenicities, coccidiosis is the most significant disease of intensive poultry production. From this, it is evident that today’s intensive poultry production would not be possible without the control of coccidiosis by coccidiostats or vaccination. Coccidiostats, i.e. polyether ionophores, differ from other antimicrobial substances. They are specified as transport antibiotics as they act by incorporation into the cell membrane through the formation of an ionic tunnel, causing ion loss and cell damage. Coccidiostats are often detected in feed for non-target animals as a result of cross- contamination during industrial production.
Studies on the occurrence of coccidiostats in animal tissues or elimination time from theorganismareratherscarce.Hensarethe most common non-target group exposed to coccidiostats. This is an overview of the scientific experiments examining coccidostats and their accumulations and depletion times. The affinity of the compound to accumulate in tissues after implementation depends on its chemical properties, such as molar mass, lipophilicity, dissociation constant and protein binding affinity. In summarising the current literature on the presence of coccidiostats in eggs, it can be concluded that if the substances dominate in egg yolk as residuals, the depletion time is likely to be longer than 10 days. This can be interpreted by the fact that egg yolk development begins a few days prior to hatching, e.g. in the liver, where the first egg yolk precursors are formed. In comparison, egg whites develop only hours before hatching. Therefore, the frequency of residues occurring in non-target tissues is dependent not only on the degree of contamination of the feed mixture for non-target groups, but also on the pharmacokinetic properties and the rate of accumulation of each individual coccidiostat.
Ključne riječi
coccidiostats; depletion time; poultry
Hrčak ID:
222680
URI
Datum izdavanja:
4.12.2017.
Posjeta: 1.113 *