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LENGTH HETEROPLASMY IN THE PREDOMINATE MITOCHONDRIAL DNA HAPLOGROUPS IN THE CROATIAN POPULATION

Lucija Barbaric   ORCID icon orcid.org/0000-0003-0898-7818 ; Forensic Science Center “Ivan Vučetić”, Ministry of Interior, Zagreb, Croatia
Korana Lipovac ; Forensic Science Center “Ivan Vučetić”, Ministry of Interior, Zagreb, Croatia
Viktorija Sukser ; Forensic Science Center “Ivan Vučetić”, Ministry of Interior, Zagreb, Croatia
Sara Rozic ; Forensic Science Center “Ivan Vučetić”, Ministry of Interior, Zagreb, Croatia
Marina Korolija ; Forensic Science Center “Ivan Vučetić”, Ministry of Interior, Zagreb, Croatia

Puni tekst: engleski, pdf (429 KB) str. 19-23 preuzimanja: 49* citiraj
APA 6th Edition
Barbaric, L., Lipovac, K., Sukser, V., Rozic, S. i Korolija, M. (2019). LENGTH HETEROPLASMY IN THE PREDOMINATE MITOCHONDRIAL DNA HAPLOGROUPS IN THE CROATIAN POPULATION. Molecular and Experimental Biology in Medicine, 2 (1), 19-23. Preuzeto s https://hrcak.srce.hr/224339
MLA 8th Edition
Barbaric, Lucija, et al. "LENGTH HETEROPLASMY IN THE PREDOMINATE MITOCHONDRIAL DNA HAPLOGROUPS IN THE CROATIAN POPULATION." Molecular and Experimental Biology in Medicine, vol. 2, br. 1, 2019, str. 19-23. https://hrcak.srce.hr/224339. Citirano 31.05.2020.
Chicago 17th Edition
Barbaric, Lucija, Korana Lipovac, Viktorija Sukser, Sara Rozic i Marina Korolija. "LENGTH HETEROPLASMY IN THE PREDOMINATE MITOCHONDRIAL DNA HAPLOGROUPS IN THE CROATIAN POPULATION." Molecular and Experimental Biology in Medicine 2, br. 1 (2019): 19-23. https://hrcak.srce.hr/224339
Harvard
Barbaric, L., et al. (2019). 'LENGTH HETEROPLASMY IN THE PREDOMINATE MITOCHONDRIAL DNA HAPLOGROUPS IN THE CROATIAN POPULATION', Molecular and Experimental Biology in Medicine, 2(1), str. 19-23. Preuzeto s: https://hrcak.srce.hr/224339 (Datum pristupa: 31.05.2020.)
Vancouver
Barbaric L, Lipovac K, Sukser V, Rozic S, Korolija M. LENGTH HETEROPLASMY IN THE PREDOMINATE MITOCHONDRIAL DNA HAPLOGROUPS IN THE CROATIAN POPULATION. Molecular and Experimental Biology in Medicine [Internet]. 2019 [pristupljeno 31.05.2020.];2(1):19-23. Dostupno na: https://hrcak.srce.hr/224339
IEEE
L. Barbaric, K. Lipovac, V. Sukser, S. Rozic i M. Korolija, "LENGTH HETEROPLASMY IN THE PREDOMINATE MITOCHONDRIAL DNA HAPLOGROUPS IN THE CROATIAN POPULATION", Molecular and Experimental Biology in Medicine, vol.2, br. 1, str. 19-23, 2019. [Online]. Dostupno na: https://hrcak.srce.hr/224339. [Citirano: 31.05.2020.]

Sažetak
Mitochondrial control region represents the most variable segment of the mitochondrial genome. The frequency and pattern of heteroplasmy has been described in several studies; however, none of the reports documented the Croatian population. In the present study, we screened the control region (1122 bp) of 95 individuals belonging to two predominant mitochondrial phylogenetic branches in the Croatian population, haplogroups H and U. Length heteroplasmy occurred in polycytosine (poly-C) tracts within three hypervariable segments of the control region with the following frequencies: HVSI - 26.3%, HVSII - 52.6% and HVSIII - 7.4%. Furthermore, the association between certain polymorphisms in HVSI and length heteroplasmy was investigated. Our results indicate that only polymorphisms located in the poly-C tract are associated with HVSI length heteroplasmy. The T to C transition at np 16189 is significantly associated with the occurrence of length heteroplasmy (p<0.0001). This effect was even stronger if the C insertion was present in the position 16193. The data support the hypothesis that an uninterrupted poly-C tract of more than eight cytosines leads to length heteroplasmy. Length heteroplasmy associated with the T to C substitution in np 16189 was predominantly found in haplogroup U.

Ključne riječi
mitochondrial DNA; control region; length heteroplasmy; Croatian population

Hrčak ID: 224339

URI
https://hrcak.srce.hr/224339

Posjeta: 105 *