Izvorni znanstveni članak

Cholesterol and Chloride in Acute Heart Failure

Bojana Radulović ; Zagreb University Hospital Centre, Zagreb, Croatia
Ines Potočnjak ; Sestre milosrdnice University Hospital Centre, Zagreb, Croatia
Sanda Dokoza Terešak ; Sestre milosrdnice University Hospital Centre, Zagreb, Croatia
Matias Trbušić ; Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; University of Zagreb School of Medicine, Zagreb, Croatia
Nada Vrkić ; Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; University of Zagreb Faculty of Pharmacy and Biochemistry, Zagreb, Croatia
Azra Huršidić Radulović ; Occupational Medicine Office, Zagreb, Croatia
Neven Starčević ; Sveti Duh University Hospital, Zagreb, Croatia
Milan Milošević ; Andrija Štampar School of Public Health, University of Zagreb School of Medicine, Zagreb, Croatia
Vesna Degoricija ; Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; University of Zagreb School of Medicine, Zagreb, Croatia
Saša Frank ; Institute of Molecular Biology and Biochemistry, Centre of Molecular Medicine, Medical University of Graz, Graz, Austria

Sažetak

Detecting predictors of poor outcome is crucial for understanding the underlying pathophysiology of heart failure (HF) and thus creating new therapeutic concepts. It is well established that low serum lipid levels are associated with unfavorable outcomes in HF patients. Several
studies examined the association between serum lipids and established predictors of mortality in HF patients. The aim of the present study was to examine the association of serum lipid and chloride concentrations, as well as their impact on survival in acute heart failure (AHF). The present study was performed as a prospective, single-centre, observational research. The study included 152 patients with AHF. Spearman’s correlation coefficient revealed a significant positive correlation of serum chloride levels with serum levels of total cholesterol (ρ 0.221, p=0.006), low-density lipoprotein cholesterol (LDL-c) (ρ 0.187, p=0.015) and high-density lipoprotein-cholesterol (HDL-c) (ρ 0.169, p=0.038). Binary logistic regression revealed a significant association of chloride, total cholesterol and LDL-c serum levels measured at admission with hospital survival (OR 1.077, CI 1.01-1.154, p=0.034), (OR 1.731, CI 1.090-2.748, p=0.020) and (OR 1.839, CI 1.033-3.274, p=0.038), respectively, as well as with 3-month survival (OR 1.065, CI 1.002-1.131, p=0.042), (OR 1.625, CI 1.147-2.303, p=0.006) and (OR 1.711, CI 1.117-2.622, p=0.014), respectively. In conclusion, positive statistical association between serum cholesterol (total cholesterol, LDL-c and HDL-c) and chloride levels may suggest
their similar modulation by AHF pathophysiology. Serum levels of total cholesterol, LDL-c and chloride contribute to patient survival.

Ključne riječi

Heart failure; Cholesterol, LDL; Cholesterol, HDL; Lipids; Chloride

Hrčak ID:

224346

URI

https://hrcak.srce.hr/224346

Datum izdavanja:

1.6.2019.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.807 *