Acta clinica Croatica, Vol. 58. No. 2., 2019.
Izvorni znanstveni članak
https://doi.org/10.20471/acc.2019.58.02.04
Characteristics of Treatment and Outcome in Elderly Patients with Brain Glioblastoma: a Retrospective Analysis of Case Series
Mauro Dobran
orcid.org/0000-0001-7305-6951
; Department of Neurosurgery Università Politecnica delle Marche, Ospedali Riuniti di Ancona, Ancona, Italy
Davide Nasi
; Department of Neurosurgery Università Politecnica delle Marche, Ospedali Riuniti di Ancona, Ancona, Italy
Martina Della Costanza
; Department of Neurosurgery Università Politecnica delle Marche, Ospedali Riuniti di Ancona, Ancona, Italy
Maurizio Gladi
; Department of Neurosurgery Università Politecnica delle Marche, Ospedali Riuniti di Ancona, Ancona, Italy
Maurizio Iacoangeli
; Department of Neurosurgery Università Politecnica delle Marche, Ospedali Riuniti di Ancona, Ancona, Italy
Krešimir Rotim
; Department of Neurosurgery, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia
Bruno Splavski
; Department of Neurosurgery, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia
Sažetak
Treatment modalities affecting quality of life and survival in elderly brain glioblastoma patients are not well defined. A single-institution data were analyzed during a 3-year period to disclose prognostic difference in management related to age. Karnofsky Performance Scale (KPS), overall survival (OS), and adjuvant therapy were evaluated. The case group comprised of elderly patients (>75 years), while the control group included those of younger age (<65 years). The investigated
variables were correlated between the groups. Twenty elderly patients and a corresponding number of younger ones were analyzed. Preoperative KPS >70 indicated longer overall survival. Statistically significant correlation was recorded in both the control (p=0.036) and case (p=0.0053) groups. Lower postoperative KPS was significantly correlated with shorter OS in elderly patients (p=0.023). The correlation between the extent of tumor resection and OS was statistically significant in younger patients only (p=0.04). Overall survival was significantly shorter in elderly patients regardless of the extent
of tumor resection (p=0.0057). Adjuvant therapy was significantly associated with longer OS in both the case (p=0.032) and control (p=0.013) groups. Elderly population is a more endangered group
of surgical brain glioblastoma patients having lower quality of life and shorter overall survival. The management protocol should be personalized for each individual case in this age group of patients to
reduce postoperative complications and grant a satisfactory quality of life.
Ključne riječi
Elderly patients; Glioblastoma; Management outcome; Prognosis; Treatment modalities
Hrčak ID:
224350
URI
Datum izdavanja:
1.6.2019.
Posjeta: 1.350 *