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https://doi.org/10.2478/acph-2020-0022

Differential effects of acute and chronic treatment with the flavonoid chrysin on anxiety-like behavior and Fos immunoreactivity in the lateral septal nucleus in rats

LEÓN JESÚS GERMÁN-PONCIANO ; Programa de Posgrado en Neuroetología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa 91190, Veracruz, México; Laboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa 91190, Veracruz, México
ABRAHAM PUGA-OLGUÍN orcid id orcid.org/0000-0002-5968-0210 ; Programa de Posgrado en Neuroetología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa 91190, Veracruz, México; Laboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa 91190, Veracruz, México
MARIA DE JESÚS ROVIROSA-HERNÁNDEZ ; Instituto de Neuroetología, Universidad Veracruzana, Xalapa 91190, Veracruz, México
MARIO CABA ; Centro de Investigaciones Biomédicas, Universidad Veracruzana, Xalapa 91190, Veracruz, México
ENRIQUE MEZA ; Centro de Investigaciones Biomédicas, Universidad Veracruzana, Xalapa 91190, Veracruz, México
JUAN FRANCISCO RODRÍGUEZ-LANDA orcid id orcid.org/0000-0001-5837-103X ; Laboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa 91190, Veracruz, México; Facultad de Química Farmacéutica Biológica, Universidad Veracruzana, Xalapa 91000, Veracruz, México


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preuzimanja: 449

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Sažetak

The aim of this study was to compare the effects of acute (a single injection) and chronic (21 consecutive days) treatments with chrysin 2, 4, and 8 umol kg–1 on anxiety-like behavior and Fos immunoreactivity in the lateral septum nucleus (LSN), a structure that is involved in the regulation of anxiety, in male Wistar rats. These effects were compared with the clinically effective anxiolytic diazepam 7 umol kg–1. The results showed that acute, but not chronic treatment, with 4 umol kg-1 chrysin exerted anxiolytic- and antidepressant-like effects, andwith these effects were being similar to that of diazepam. Also, none of the above above-mentioned treatments did alter Fos immunoreactivity in the LSN, but a tendency towards athe reduction of this variable was detected with chrysin 4 umol kg–1 and diazepam 7 umol kg–1. Altogether, results suggest that chrysin exerts anxiolytic-like effects, but however, it can produce pharmacological tolerance after repeated use, similar to benzodiazepines.

Ključne riječi

chrysin; anxiolytic; elevated plus maze; Fos protein; lateral septal nucleus

Hrčak ID:

225574

URI

https://hrcak.srce.hr/225574

Datum izdavanja:

30.9.2020.

Posjeta: 1.045 *