Medica Jadertina, Vol. 49 No. 2, 2019.
Stručni rad
Clinical significance nontuberculous mycobacteria isolation in patients treated for pulmonary tuberculosis
Boris Vrga
; Opća bolnica "Dr. Ivo Pedišić" Sisak - lokacija u Petrinji
Boris Vrga ml.
; Sveučilište "Josip Juraj Strossmayer"Osijek, Medicinski fakultet
Sažetak
The clinical aspect of the isolation of Nontuberculous Mycobacteria from samples taken from the respiratory tract (expectorate, bronchial aspirate, bronchoalveolar lavage) in patients with pulmonary TB in Croatia is still not known enough. The aim of the paper is to define the frequency and the clinical significance of the co-isolation as well as the subsequent isolation of Nontuberculous Mycobacteria (NTM) in patients with active pulmonary TB in Sisak-Moslavina county, which has had the highest incidence of TB in Croatia for the last two decades. There has been a retrospective analysis of data derived from positive sample cultures from the respiratory tract on Mycobacterium Tuberculosis in 285 patients, who, due to active pulmonary TB, underwent hospital treatment alongside with being checked as outpatients in the Pulmonary Ward of GH “Dr Ivo Pedišić” Sisak – location in Petrinja, and in whom NTM, too, were identified in their culture. What was used to determine the clinical relevance of the NTM isolate were the revised criteria of the American Thoracic Society (ATS) and Infectious Diseases Society of America (IDSA) from 2007. This first clinical analysis of the stated phenomenon in Croatia resulted in the registration of four patients with NTM isolation (1.4%) and two patients in whom the NTM isolates were identified after treatment had been completed (0.7%). Three patients had two-fold (50%), and three patients had one-fold NTM isolates. The complete ATS/IDSA criteria for pulmonary mycobacteriosis were not met in neither one of them and in all of them a spontaneous conversion of sputum to NTM developed. It can be concluded that the issue in all the cases was the colonization of the respiratory tract by NTM without the development of clinically relevant pulmonary infection.
Ključne riječi
mycobacterium tuberculosis; nontuberculous mycomacteria (NTM); NTM coisolation; NTM co-infection; subsequent NTM isolation; tuberculosis
Hrčak ID:
225795
URI
Datum izdavanja:
1.10.2019.
Posjeta: 1.842 *