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https://doi.org/10.15836/ccar2019.215

Exploring the relationship between smoking status and the total number of coronary arteries with significant stenoses in a young population with ST-segment elevation myocardial infarction

Filip Puškarić orcid.org/0000-0001-5519-439X ; University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia
Zvonimir Ostojić ; University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia
Nina Jakuš ; University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia
Ivo Planinc orcid.org/0000-0003-0561-6704 ; University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia
Marijan Pašalić ; University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia
Joško Bulum ; University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia
Davor Miličić ; University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia
Maja Čikeš ; University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia

Sažetak

Background: A plethora of studies have proven the increase in cardiovascular risk associated with smoking in all age groups1, including the one at the focus of this study – the young2,3. With regard to the total number of coronary arteries (CA) with significant stenoses, one might expect current smokers to have more affected CA than non- and former smokers. Aim: To explore the relationship between smoking status and the total number of CA with significant stenoses in a young ST-segment elevation myocardial infarction (STEMI) population.
Patients and Methods: Data were attained from medical records of 147 patients (mean age 43.9±6.5 years) hospitalized with STEMI at the University Hospital Centre Zagreb from January 2012 to October
2018, with a cut-off age at 45 years for men (n = 93) and 55 years for women (n = 54). Patients were divided in 2 groups based on smoking status – non- and former smokers (N = 29 (20%), with former
smokers making up 9/29 or 31% of the group), and current smokers (N = 118 (80%)). To evaluate whether smoking status was associated with a higher total number of CA with significant stenoses, Pearson’s
chi-squared test was performed. During post hoc testing, the p value was adjusted to maintain the familywise error rate at 0.05 (p = 0.008) and compared to p values of each subgroup.
Results: The two groups had no significant differences in baseline characteristics (Table 1). In both groups, the majority of patients (58.6% vs. 74.6%) had only one affected CA, followed by two (27.6% vs. 19.5%) and three (13.8% vs. 5.9%) CA. Pearson’s chi-squared test showed no statistically significant difference in the total number of affected CA between the two groups (p = 0.176). Post hoc testing
confirmed statistically insignificant associations in all subgroups (p > 0.008, Table 2). In multiple regression (F (2, 144) = 9.27, p < 0.001, R2 adjusted = 0.10), age (B = 0.03, p = 0.001) and family history for cardiovascular disease (B = 0.30, p = 0.003) remained associated with the number of affected CA.

Ključne riječi

acute coronary syndrome; ST-segment elevation myocardial infarction; young; smoking; coronary angiography

Hrčak ID:

226688

URI

https://hrcak.srce.hr/226688

Datum izdavanja:

15.10.2019.

Posjeta: 792 *