Cardiologia Croatica, Vol. 14 No. 9-10, 2019.
Sažetak sa skupa
https://doi.org/10.15836/ccar2019.263
Mineralocorticoid Receptor Antagonist Eplerenone in Cardiovascular Disease
Ivo Planinc
orcid.org/0000-0003-0561-6704
Sažetak
Aldosterone and eplerenone are mineralocorticoid receptor antagonists with one of the main roles in the treatment of heart failure, as demonstrated by large randomized controlled trials. Effects on patient outcomes are the result of blocking the renin-angiotensin-aldosterone system, which improves cardiac remodeling. Besides heart failure, mineralocorticoid receptor antagonists are used in treatment of patients with resistant arterial hypertension. This review focuses on the pharmacokinetics, pharmacodynamics, clinical effects, and safety profile of eplerenone.
Ključne riječi
mineralocorticoid receptor antagonists; eplerenone; heart failure; arterial hypertension; hyperkalemia
Hrčak ID:
226723
URI
Datum izdavanja:
15.10.2019.
Posjeta: 1.930 *