Izvorni znanstveni članak
https://doi.org/10.21857/9xn31crexy
High-fat Diet Induced Dysbiosis & Amelioration by Astaxanthin
Kyle Haasbroek
; Centar za medicinska istraživanja protiv starenja i Centar za istraživanje stresa glikacije
Wakako Takabe
; Centar za medicinska istraživanja protiv starenja i Centar za istraživanje stresa glikacije
Masayuki Yagi
; Centar za medicinska istraživanja protiv starenja i Centar za istraživanje stresa glikacije
Yoshikazu Yonei
; Centar za medicinska istraživanja protiv starenja i Centar za istraživanje stresa glikacije
Sažetak
Astaxanthin is a carotenoid that is present in high quantities in the meat of fish like salmon and the shells of shrimp and crab. It exhibits free radical scavenging antioxidant activity when consumed di- etarily. Astaxanthin is absorbed by the small intestine before exerting its antioxidant effect; however, a portion of dietary intake remains unabsorbed in the digestive tract and reaches the large intes- tines . We hypothesized that astaxanthin may exert its antioxidant action in the large intestine to influence the gut microbiota. In this review we introduce the results of two studies of astaxanthin. Firstly, a clinical trial targeting post-menopausal women screened for high oxidative stress burden. Astaxanthin was administered orally for eight weeks in order to examine its effects and safety, and subjects were surveyed for any changes in subjective symptoms. Secondly, in a mouse model, real time PCR (polymerase chain reaction) was used to examine the ability of astaxanthin to prevent changes in the enteric flora induced by a high-fat diet. When fat intake increases due to changes in diet, the equilibrium between the various species that constitute the intestinal flora is altered. As a result, degenerative changes in lifestyle-related disease and aging of the host are promoted. Here we find that the intake of astaxanthin was able to inhibit these changes in the gut microbiota of mice induced by a high-fat diet. Even in humans, it is highly probably that the unabsorbed astaxanthin that remains in the intestinal tract exerts a positive effect against disturbance of the intestinal flora caused by a high-fat diet.
Ključne riječi
Astaxanthin; Gut microbiota; Antioxidant; High fat diet; Dysbiosis
Hrčak ID:
231560
URI
Datum izdavanja:
17.12.2019.
Posjeta: 1.253 *