Izvorni znanstveni članak
https://doi.org/10.5599/jese.732
Poly(vinyl alcohol)/chitosan hydrogels with electrochemically synthesized silver nanoparticles for wound dressing applications
Katarina Nešović
orcid.org/0000-0002-9022-6032
; University of Belgrade, Faculty of Technology and Metallurgy, Belgrade, Serbia
Ana Janković
; University of Belgrade, Faculty of Technology and Metallurgy, Belgrade, Serbia
Tamara Radetić
; University of Belgrade, Faculty of Technology and Metallurgy, Belgrade, Serbia
Aleksandra Perić-Grujić
orcid.org/0000-0002-2593-4796
; University of Belgrade, Faculty of Technology and Metallurgy, Belgrade, Serbia
Maja Vukašinović-Sekulić
; University of Belgrade, Faculty of Technology and Metallurgy, Belgrade, Serbia
Vesna Kojić
orcid.org/0000-0002-2399-0807
; University of Novi Sad, Faculty of Medicine, Oncology Institute of Vojvodina, Sremska Kamenica, Serbia
Kyong Yop Rhee
; Kyung Hee University, Department of Mechanical Engineering, Yongin, South Korea
Vesna Mišković-Stanković
orcid.org/0000-0001-6525-9820
; University of Belgrade, Faculty of Technology and Metallurgy, Belgrade, Serbia
Sažetak
Polymer-based hydrogel materials are excellent candidates for new-generation wound dressings with improved properties, such as high sorption ability, good mechanical properties and low adhesiveness. Cross-linked hydrogel matrices also serve as excellent carriers for controlled release of antibacterial agents, such as silver nanoparticles (AgNPs), which are preferred over conventional antibiotics due to low propensity to induce bacterial resistance. In this work, we aim to produce novel silver/poly(vinyl alcohol)/chitosan (Ag/PVA/CHI) hydrogels for wound dressing applications. The electrochemical AgNPs synthesis provided facile and green method for the reduction of Ag+
ions inside the hydrogel matrices, without the need to use toxic chemical reducing agents. The formation of AgNPs was confirmed using UV-visible spectroscopy, scanning and transmission electron microscopy. Release kinetics was investigated in modified phosphate buffer solution at 37 °C to mimic physiological conditions. Release profiles indicated “burst release” behavior, which is beneficial for wound dressing applications. The antibacterial activity was evaluated against Staphylococcus aureus and Escherichia coli strains using disc-diffusion test, and non-toxicity of hydrogels was proved by dye-exclusion test. The obtained results confirmed strong potential of Ag/PVA/CHI hydrogels for biomedical applications.
Ključne riječi
Electrochemical synthesis; hydrogels; release kinetics; antibacterial activity; wound dressings
Hrčak ID:
235504
URI
Datum izdavanja:
10.3.2020.
Posjeta: 907 *