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https://doi.org/10.2478/aiht-2020-71-3314

Gamma-hydroxybutyrate abuse: pharmacology and poisoning and withdrawal management

Enrico Marinelli   ORCID icon orcid.org/0000-0002-7104-8744 ; Department of Anatomical, Histological, Forensic, and Orthopaedic Sciences, Sapienza University of Rome, Rome, Italy
Renata Beck   ORCID icon orcid.org/0000-0001-8352-7219 ; Department of Anaesthesia, Santa Maria Hospital, GVM Care & Research, Bari, Italy
Antonio Malvasi ; Department of Obstetrics and Gynaecology, Santa Maria Hospital, Bari, Italy
Alfredo Fabrizio Lo Faro ; Section of Legal Medicine, Department of Excellence SBSP, University “Politecnica delle Marche” of Ancona, Ancona, Italy
Simona Zaami ; Department of Anatomical, Histological, Forensic, and Orthopaedic Sciences, Sapienza University of Rome, Rome, Italy

Puni tekst: engleski, pdf (437 KB) str. 19-26 preuzimanja: 153* citiraj
APA 6th Edition
Marinelli, E., Beck, R., Malvasi, A., Lo Faro, A.F. i Zaami, S. (2020). Gamma-hydroxybutyrate abuse: pharmacology and poisoning and withdrawal management. Arhiv za higijenu rada i toksikologiju, 71 (1), 19-26. https://doi.org/10.2478/aiht-2020-71-3314
MLA 8th Edition
Marinelli, Enrico, et al. "Gamma-hydroxybutyrate abuse: pharmacology and poisoning and withdrawal management." Arhiv za higijenu rada i toksikologiju, vol. 71, br. 1, 2020, str. 19-26. https://doi.org/10.2478/aiht-2020-71-3314. Citirano 25.02.2021.
Chicago 17th Edition
Marinelli, Enrico, Renata Beck, Antonio Malvasi, Alfredo Fabrizio Lo Faro i Simona Zaami. "Gamma-hydroxybutyrate abuse: pharmacology and poisoning and withdrawal management." Arhiv za higijenu rada i toksikologiju 71, br. 1 (2020): 19-26. https://doi.org/10.2478/aiht-2020-71-3314
Harvard
Marinelli, E., et al. (2020). 'Gamma-hydroxybutyrate abuse: pharmacology and poisoning and withdrawal management', Arhiv za higijenu rada i toksikologiju, 71(1), str. 19-26. https://doi.org/10.2478/aiht-2020-71-3314
Vancouver
Marinelli E, Beck R, Malvasi A, Lo Faro AF, Zaami S. Gamma-hydroxybutyrate abuse: pharmacology and poisoning and withdrawal management. Arh Hig Rada Toksikol. [Internet]. 2020 [pristupljeno 25.02.2021.];71(1):19-26. https://doi.org/10.2478/aiht-2020-71-3314
IEEE
E. Marinelli, R. Beck, A. Malvasi, A.F. Lo Faro i S. Zaami, "Gamma-hydroxybutyrate abuse: pharmacology and poisoning and withdrawal management", Arhiv za higijenu rada i toksikologiju, vol.71, br. 1, str. 19-26, 2020. [Online]. https://doi.org/10.2478/aiht-2020-71-3314

Sažetak
Gamma-hydroxybutyrate (GHB) is a central nervous system depressant primarily used as a recreational drug of abuse, but also for the treatment of narcolepsy with cataplexy in adult patients and as an adjuvant for control of alcohol withdrawal syndrome. The main aim of this review is to summarise updated knowledge about GHB pharmacokinetics and pharmacodynamics, acute poisoning, and clinical features of GHB withdrawal syndrome, its diagnosis and medical treatment. The most common clinical signs and symptoms of acute poisoning include sleepiness to deep coma, bradycardia, hypotension, and respiratory failure. Therapy is essentially supportive and based on continuous monitoring of vital signs. GHB withdrawal syndrome shares patterns with other withdrawal syndromes such as alcohol withdrawal and is sometimes difficult to distinguish, especially if toxicological tests are GHB-negative or cannot be performed. There are no official detoxification protocols for GHB withdrawal syndrome, but its therapy is based on benzodiazepine. When benzodiazepine alone is not effective, it can be combined with barbiturates or antipsychotics. Information about abuse and distribution of GHB and its precursors/analogues among the general population is still limited. Their prompt identification is therefore crucial in conventional and non-conventional biological matrices, the latter in particular, to clarify all the issues around this complex molecule.

Ključne riječi
acute toxicity; GABA; gamma-aminobutyric acid; gamma-butyrolactone; 1,4-butanediol; GHB; pharmacodynamics; pharmacokinetics; withdrawal syndrome

Hrčak ID: 236202

URI
https://hrcak.srce.hr/236202

[hrvatski]

Posjeta: 356 *