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https://doi.org/10.2478/aiht-2020-71-3303

Reproductive disorders in male rats induced by highfructose consumption from juvenile age to puberty

Oleksandr Y. Tkachenko ; Toxicology Department, Institute of Pharmacology and Toxicology of NAMS of Ukraine, Kyiv, Ukraine
Ganna M. Shayakhmetova ; Toxicology Department, Institute of Pharmacology and Toxicology of NAMS of Ukraine, Kyiv, Ukraine
Anatoliy V. Matvienko ; Toxicology Department, Institute of Pharmacology and Toxicology of NAMS of Ukraine, Kyiv, Ukraine
Valentina M. Kovalenko ; Toxicology Department, Institute of Pharmacology and Toxicology of NAMS of Ukraine, Kyiv, Ukraine

Puni tekst: engleski, pdf (879 KB) str. 78-86 preuzimanja: 125* citiraj
APA 6th Edition
Tkachenko, O.Y., Shayakhmetova, G.M., Matvienko, A.V. i Kovalenko, V.M. (2020). Reproductive disorders in male rats induced by highfructose consumption from juvenile age to puberty. Arhiv za higijenu rada i toksikologiju, 71 (1), 78-86. https://doi.org/10.2478/aiht-2020-71-3303
MLA 8th Edition
Tkachenko, Oleksandr Y., et al. "Reproductive disorders in male rats induced by highfructose consumption from juvenile age to puberty." Arhiv za higijenu rada i toksikologiju, vol. 71, br. 1, 2020, str. 78-86. https://doi.org/10.2478/aiht-2020-71-3303. Citirano 06.03.2021.
Chicago 17th Edition
Tkachenko, Oleksandr Y., Ganna M. Shayakhmetova, Anatoliy V. Matvienko i Valentina M. Kovalenko. "Reproductive disorders in male rats induced by highfructose consumption from juvenile age to puberty." Arhiv za higijenu rada i toksikologiju 71, br. 1 (2020): 78-86. https://doi.org/10.2478/aiht-2020-71-3303
Harvard
Tkachenko, O.Y., et al. (2020). 'Reproductive disorders in male rats induced by highfructose consumption from juvenile age to puberty', Arhiv za higijenu rada i toksikologiju, 71(1), str. 78-86. https://doi.org/10.2478/aiht-2020-71-3303
Vancouver
Tkachenko OY, Shayakhmetova GM, Matvienko AV, Kovalenko VM. Reproductive disorders in male rats induced by highfructose consumption from juvenile age to puberty. Arh Hig Rada Toksikol. [Internet]. 2020 [pristupljeno 06.03.2021.];71(1):78-86. https://doi.org/10.2478/aiht-2020-71-3303
IEEE
O.Y. Tkachenko, G.M. Shayakhmetova, A.V. Matvienko i V.M. Kovalenko, "Reproductive disorders in male rats induced by highfructose consumption from juvenile age to puberty", Arhiv za higijenu rada i toksikologiju, vol.71, br. 1, str. 78-86, 2020. [Online]. https://doi.org/10.2478/aiht-2020-71-3303

Sažetak
There is compelling evidence that a hypercaloric, high-fructose diet can cause metabolic syndrome (MetS) and a whole range of other metabolic changes. In the context of androgen deficiency, MetS in boys merits special attention, but the effects of fructose-rich diet in youth on future male reproductive function are still poorly evidenced. The aim of this study was to address this issue and analyse the effects of high-fructose intake starting from weaning to puberty (postnatal day 23 up to 83) on the reproductive function of male rats. For this purpose juvenile male Wistar rats were divided in two groups: control and the group receiving 10 % fructose solution instead of drinking water. Reproductive function was evaluated in terms of fertility, sperm count, testes/epididymis morphology, and serum sex hormones. The fructose-treated group showed a decrease in testosterone and twofold increase in luteinising and follicle-stimulating hormone levels in the serum. This was accompanied with lower testis/epididymis weights, sperm count, and changed testis/epididymis morphology. Their fertility remained unchanged, but the fertility of females mating with these males diminished. In addition, pre-implantation and post-implantation embryonic death rate rose in these females. Our results have confirmed that high fructose consumption from early age until puberty can impair the reproductive function of male rats, and call for further animal and epidemiological investigation.

Ključne riječi
epididymis; fertility; FSH; LH; male reproductive function; metabolic syndrome; MetS; sperm count; testes; testosterone

Hrčak ID: 236216

URI
https://hrcak.srce.hr/236216

[hrvatski]

Posjeta: 254 *