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https://doi.org/10.5562/cca3597

Screening of Natural Deep Eutectic Solvents for Green Synthesis of 2-methyl-3-substituted Quinazolinones and Microwave-Assisted Synthesis of 3-aryl Quinazolinones in Ethanol

Mario Komar ; Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology, F. Kuhača 20, HR-31000 Osijek, Croatia
Maja Molnar ; Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology, F. Kuhača 20, HR-31000 Osijek, Croatia
Anastazija Konjarević ; Croatian Veterinary Institute-Branch Veterinary Institute Vinkovci, J. Kozarca 24, HR-32100 Vinkovci, Croatia

Puni tekst: engleski, pdf (2 MB) str. 511-517 preuzimanja: 207* citiraj
APA 6th Edition
Komar, M., Molnar, M. i Konjarević, A. (2019). Screening of Natural Deep Eutectic Solvents for Green Synthesis of 2-methyl-3-substituted Quinazolinones and Microwave-Assisted Synthesis of 3-aryl Quinazolinones in Ethanol. Croatica Chemica Acta, 92 (4), 511-517. https://doi.org/10.5562/cca3597
MLA 8th Edition
Komar, Mario, et al. "Screening of Natural Deep Eutectic Solvents for Green Synthesis of 2-methyl-3-substituted Quinazolinones and Microwave-Assisted Synthesis of 3-aryl Quinazolinones in Ethanol." Croatica Chemica Acta, vol. 92, br. 4, 2019, str. 511-517. https://doi.org/10.5562/cca3597. Citirano 02.03.2021.
Chicago 17th Edition
Komar, Mario, Maja Molnar i Anastazija Konjarević. "Screening of Natural Deep Eutectic Solvents for Green Synthesis of 2-methyl-3-substituted Quinazolinones and Microwave-Assisted Synthesis of 3-aryl Quinazolinones in Ethanol." Croatica Chemica Acta 92, br. 4 (2019): 511-517. https://doi.org/10.5562/cca3597
Harvard
Komar, M., Molnar, M., i Konjarević, A. (2019). 'Screening of Natural Deep Eutectic Solvents for Green Synthesis of 2-methyl-3-substituted Quinazolinones and Microwave-Assisted Synthesis of 3-aryl Quinazolinones in Ethanol', Croatica Chemica Acta, 92(4), str. 511-517. https://doi.org/10.5562/cca3597
Vancouver
Komar M, Molnar M, Konjarević A. Screening of Natural Deep Eutectic Solvents for Green Synthesis of 2-methyl-3-substituted Quinazolinones and Microwave-Assisted Synthesis of 3-aryl Quinazolinones in Ethanol. Croatica Chemica Acta [Internet]. 2019 [pristupljeno 02.03.2021.];92(4):511-517. https://doi.org/10.5562/cca3597
IEEE
M. Komar, M. Molnar i A. Konjarević, "Screening of Natural Deep Eutectic Solvents for Green Synthesis of 2-methyl-3-substituted Quinazolinones and Microwave-Assisted Synthesis of 3-aryl Quinazolinones in Ethanol", Croatica Chemica Acta, vol.92, br. 4, str. 511-517, 2019. [Online]. https://doi.org/10.5562/cca3597

Sažetak
In this study, two fast and efficient protocols for green synthesis of 3-substituted quinazolinones were perfomed. A synthesis of
2-methyl-3-substituted quinazolinones was performed in natural deep eutectic solvents, while 3-aryl quinazolinones were obtained by using microwave assisted synthesis. Benzoxazinone, which was used as an intermediate in the synthesis of 2-methyl-3-substituted quinazolinones, was prepared conventionally from anthranilic acid and acetic anhydride. In order to find the most appropriate synthetic path, twenty natural deep eutectic solvents were applied as a solvent in these syntheses. Choline chloride:urea (1 : 2) was found to be the most efficient solvent and was further used in the synthesis of 2-methyl quinazolinone derivatives (2–12). 3-Aryl quinazolinones (13–17), on the other hand, were synthesized in one-pot microwave-assisted reaction of anthranilic acid, different amines and trimethyl orthoformate. All compounds were synthesized in good to excellent yields, characterized by LC-MS/MS spectrometry and 1H- and 13C-NMR spectroscopy.

Creative Commons License This work is licensed under a Creative Commons Attribution 4.0 International License.

Ključne riječi
natural deep eutectic solvents; microwave-assisted synthesis; quinazolinones; anthranilic acid; amine

Hrčak ID: 236327

URI
https://hrcak.srce.hr/236327

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