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Izvorni znanstveni članak
https://doi.org/10.2478/acph-2021-0010

Investigation of design space for freeze-drying injectable ibuprofen using response surface methodology

MAJA PRESKAR ; Krka d.d. SI-8000 Novo mesto, Slovenia
DANIJEL VIDEC ; Krka d.d. SI-8000 Novo mesto, Slovenia
FRANC VREČER ; Krka d.d. SI-8000 Novo mesto, Slovenia
MIRJANA GAŠPERLIN ; University of Ljubljana, Faculty of Pharmacy, SI-1000, Ljubljana, Slovenia

Puni tekst: engleski, pdf (2 MB) str. 81-98 preuzimanja: 105* citiraj
APA 6th Edition
PRESKAR, M., VIDEC, D., VREČER, F. i GAŠPERLIN, M. (2021). Investigation of design space for freeze-drying injectable ibuprofen using response surface methodology. Acta Pharmaceutica, 71 (1), 81-98. https://doi.org/10.2478/acph-2021-0010
MLA 8th Edition
PRESKAR, MAJA, et al. "Investigation of design space for freeze-drying injectable ibuprofen using response surface methodology." Acta Pharmaceutica, vol. 71, br. 1, 2021, str. 81-98. https://doi.org/10.2478/acph-2021-0010. Citirano 02.12.2020.
Chicago 17th Edition
PRESKAR, MAJA, DANIJEL VIDEC, FRANC VREČER i MIRJANA GAŠPERLIN. "Investigation of design space for freeze-drying injectable ibuprofen using response surface methodology." Acta Pharmaceutica 71, br. 1 (2021): 81-98. https://doi.org/10.2478/acph-2021-0010
Harvard
PRESKAR, M., et al. (2021). 'Investigation of design space for freeze-drying injectable ibuprofen using response surface methodology', Acta Pharmaceutica, 71(1), str. 81-98. https://doi.org/10.2478/acph-2021-0010
Vancouver
PRESKAR M, VIDEC D, VREČER F, GAŠPERLIN M. Investigation of design space for freeze-drying injectable ibuprofen using response surface methodology. Acta Pharm. [Internet]. 2021 [pristupljeno 02.12.2020.];71(1):81-98. https://doi.org/10.2478/acph-2021-0010
IEEE
M. PRESKAR, D. VIDEC, F. VREČER i M. GAŠPERLIN, "Investigation of design space for freeze-drying injectable ibuprofen using response surface methodology", Acta Pharmaceutica, vol.71, br. 1, str. 81-98, 2021. [Online]. https://doi.org/10.2478/acph-2021-0010

Sažetak
This study explores the use of a statistical model to build a design space for freeze-drying two formulations with ibuprofen. A 2 × 3 factorial experimental design was used to evaluate independent variables (filling volume and annealing time) and responses as residual moisture content, specific surface area and reconstitution time. A statistical model and response surface plots were generated to define the interactions among the selected variables. The models constructed for both formulations suggest that 1 ml of filled volume and no annealing should be used to achieve optimal residual moisture content, specific surface area and reconstitution time. The proposed models were validated with additional experiments, in which the responses observed were mainly in close agreement with the predicted ones. Additionally, the established models demonstrate the reliability of the evaluation procedure in predicting the selected responses.

Ključne riječi
design space; response surface method; lyophilization; ibuprofen

Hrčak ID: 236802

URI
https://hrcak.srce.hr/236802

Posjeta: 216 *