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https://doi.org/10.2478/acph-2021-0010

Investigation of design space for freeze-drying injectable ibuprofen using response surface methodology

MAJA PRESKAR ; Krka d.d. SI-8000 Novo mesto, Slovenia
DANIJEL VIDEC ; Krka d.d. SI-8000 Novo mesto, Slovenia
FRANC VREČER ; Krka d.d. SI-8000 Novo mesto, Slovenia
MIRJANA GAŠPERLIN ; University of Ljubljana, Faculty of Pharmacy, SI-1000, Ljubljana, Slovenia


Puni tekst: engleski pdf 1.803 Kb

str. 81-98

preuzimanja: 608

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Sažetak

This study explores the use of a statistical model to build a design space for freeze-drying two formulations with ibuprofen. A 2 × 3 factorial experimental design was used to evaluate independent variables (filling volume and annealing time) and responses as residual moisture content, specific surface area and reconstitution time. A statistical model and response surface plots were generated to define the interactions among the selected variables. The models constructed for both formulations suggest that 1 ml of filled volume and no annealing should be used to achieve optimal residual moisture content, specific surface area and reconstitution time. The proposed models were validated with additional experiments, in which the responses observed were mainly in close agreement with the predicted ones. Additionally, the established models demonstrate the reliability of the evaluation procedure in predicting the selected responses.

Ključne riječi

design space; response surface method; lyophilization; ibuprofen

Hrčak ID:

236802

URI

https://hrcak.srce.hr/236802

Datum izdavanja:

31.3.2021.

Posjeta: 1.232 *