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THE VALUE OF CASPASE 3 IN DIFFERENTIATING RENAL ONCOCYTOMA FROM CHROMOPHOBE RENAL CELL CARCINOMA
FRAN ČAKAR
; Sveučilište u Zagrebu, Medicinski fakultet, Zavod za patologiju, Zagreb, Hrvatska
TIHANA REGOVIĆ DŽOMBETA
orcid.org/0000-0002-8858-3524
; Sveučilište u Zagrebu, Medicinski fakultet, Zavod za patologiju i Klinički bolnički centar Sestre milosrdnice, Klinički zavod za patologiju i citologiju Ljudevit Jurak, Zagreb, Hrvatska
Sažetak
Aim: Renal oncocytoma (RO) and chromophobe renal cell carcinoma (ChRCC) are epithelial neoplasms of the kidney with overlapping histologic features, making their differential diagnosis one of the pitfalls in renal pathology. The aim of this study was to assess the level of caspase 3 expression in RO and ChRCC, in order to investigate its potential value in their differentiation. Methods: The study included 24 RO cases and 24 ChRCC cases, taken from the archives of Ljudevit Jurak Department of Pathology and Cytology, Sestre milosrdnice University Hospital Centre Zagreb. The results of immunohistochemical analysis were determined semiquantitatively using immunohistochemical staining index (ISI). Statistical analysis was done using Mann-Whitney U test. Results: All samples showed positive immunohistochemical reaction for caspase 3, with the majority of RO showing moderate ISI and the majority of ChRCC showing low ISI. Conclusion: The use of caspase-3 could favor the diagnosis of RO in cases where the tumor shows strong and diffuse staining. Further studies on a larger number of cases are needed to confi rm our results.
Ključne riječi
caspase 3; renal oncocytoma; chromophobe renal cell carcinoma; immunohistochemistry
Hrčak ID:
237917
URI
Datum izdavanja:
24.4.2020.
Posjeta: 974 *