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https://doi.org/10.46419/vs.51.6.1

Transepithelial glucose transport in the small intestine

Mirela Pavić   ORCID icon orcid.org/0000-0003-4554-3247 ; Faculty of Veterinary Medicine, University of Zagreb, Croatia
Marcela Šperanda ; Faculty of Agrobiotechnical Sciences Osijek, University of Josip Juraj Strossmayer Osijek, Croatia
Hrvoje Brzica ; Fidelta Ltd., Zagreb, Croatia
Suzana Milnković-Tur ; Faculty of Veterinary Medicine, University of Zagreb, Croatia
Manuela Grčević ; Faculty of Agrobiotechnical Sciences Osijek, University of Josip Juraj Strossmayer Osijek, Croatia
Ivana Prakatur ; Faculty of Agrobiotechnical Sciences Osijek, University of Josip Juraj Strossmayer Osijek, Croatia
Ivona Žura Žaja ; Faculty of Veterinary Medicine, University of Zagreb, Croatia
Marija Ljubojević ; Molecular Toxicology Unit, Institute for Medical Research and Occupational Health, Zagreb, Croatia

Puni tekst: engleski, pdf (523 KB) str. 673-686 preuzimanja: 114* citiraj
APA 6th Edition
Pavić, M., Šperanda, M., Brzica, H., Milnković-Tur, S., Grčević, M., Prakatur, I., ... Ljubojević, M. (2020). Transepithelial glucose transport in the small intestine. Veterinarska stanica, 51 (6), 673-686. https://doi.org/10.46419/vs.51.6.1
MLA 8th Edition
Pavić, Mirela, et al. "Transepithelial glucose transport in the small intestine." Veterinarska stanica, vol. 51, br. 6, 2020, str. 673-686. https://doi.org/10.46419/vs.51.6.1. Citirano 02.03.2021.
Chicago 17th Edition
Pavić, Mirela, Marcela Šperanda, Hrvoje Brzica, Suzana Milnković-Tur, Manuela Grčević, Ivana Prakatur, Ivona Žura Žaja i Marija Ljubojević. "Transepithelial glucose transport in the small intestine." Veterinarska stanica 51, br. 6 (2020): 673-686. https://doi.org/10.46419/vs.51.6.1
Harvard
Pavić, M., et al. (2020). 'Transepithelial glucose transport in the small intestine', Veterinarska stanica, 51(6), str. 673-686. https://doi.org/10.46419/vs.51.6.1
Vancouver
Pavić M, Šperanda M, Brzica H, Milnković-Tur S, Grčević M, Prakatur I i sur. Transepithelial glucose transport in the small intestine. Veterinarska stanica [Internet]. 2020 [pristupljeno 02.03.2021.];51(6):673-686. https://doi.org/10.46419/vs.51.6.1
IEEE
M. Pavić, et al., "Transepithelial glucose transport in the small intestine", Veterinarska stanica, vol.51, br. 6, str. 673-686, 2020. [Online]. https://doi.org/10.46419/vs.51.6.1

Sažetak
The duodenum, jejunum and ileum are parts of the small intestine and the sites of the terminal stages of enzymatic digestion, and the majority of nutrient, electrolyte and water absorption. The apical, luminal membrane of the enterocyte is built of numerous microvilli that increase the absorptive surface of the cell. Carbohydrates, in the form of monosaccharides, oligosaccharides and especially polysaccharides, make up the largest quantitative and energetic part of the diet of most animals, including humans. Galactose, fructose and glucose, the final degradation products of polysaccharide and oligosaccharide enzymatic digestion, can be absorbed by enterocytes either by active transport or by facilitated diffusion. In the small intestine, the transepithelial transport of glucose, the most abundant monosaccharide after carbohydrate digestion and the main source of energy, is performed by a specific membrane transporter located in the brush border membrane of the enterocyte, the sodiumglucose cotransporter 1 (SGLT1). While SGLT1 transports glucose across the brush border membrane, a specific basolateral membrane glucose transporter, the sodium-independent glucose transporter 2 (GLUT2), transfers glucose out of the enterocyte down the concentration gradient. The sodium-potassium pump (Na/KATPase), as a sodium and potassium ion transporter, is functionally closely related to the sodium-dependent SGLT1. Na/KATPase is responsible for maintaining the electrochemical gradient of sodium ions, as the driving force for glucose transport via SGLT1. Transepithelial transport of glucose in the small intestine and the differentiation of enterocytes occurs relatively early during the foetal period, allowing glucose to be absorbed from ingested amniotic fluid. Nutrient transport is possible along the whole villus-crypt axis during intrauterine development, while transport shifts toward the villus tip in the mature small intestine. With maturation, glucose transport rates change not only across the villus-crypt axis, but also along the proximodistal axis in the small intestine. The glucose absorption rate shows differences between subunits of the small intestine depending on the age and type of ingested carbohydrates, where complex carbohydrates replace less complex carbohydrates or disaccharides.

Ključne riječi
glucose absorption; small intestine; SGLT1; GLUT2; Na/K-ATPase

Hrčak ID: 238204

URI
https://hrcak.srce.hr/238204

[hrvatski]

Posjeta: 352 *