Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2019.60.127
Molecular mechanisms of microglia- and astrocyte-driven neurorestoration triggered by application of electromagnetic fields
Jasmina Isaković
orcid.org/0000-0001-5971-3142
; Omnion Research International, Zagreb, Croatia
Dunja Gorup
; Department of Histology and Embryology, University of Zagreb School of Medicine, Zagreb, Croatia
Dinko Mitrečić
; Department of Histology and Embryology, University of Zagreb School of Medicine, Zagreb, Croatia
Sažetak
Aim To propose potential mechanisms of action of electromagnetic
fields (EMF) on astrocytes and microglia and
to elucidate the role of heat shock proteins (HSP), adenosine
triphosphate (ATP), calcium ions (Ca2+), and hypoxia-inducible
factor 1α (HIF1α) in neurorestoration following the
application of EMF.
Methods We reviewed the existing studies within the
public domain and cross-evaluated their results in order
to conclude on the molecular mechanisms of microgliaastrocyte
crosstalk at work during EMF treatment.
Results The existing studies suggest that EMF induces
the increase of HSP70 expression and inhibition of HIF1α,
thus decreasing inflammation and allowing the microgliaastrocyte
crosstalk to initiate the formation of a glial scar
within the central nervous system. Furthermore, by potentially
up-regulating A2A and A3 adenosine receptors, EMF
increases cAMP accumulation from astrocytes and reduces
the expression of inflammatory cytokines TNF α and IL-8,
thus initiating neurorestoration. Conclusion The microglia-astrocyte crosstalk during EMF
treatment is crucial for the initiation of neurorestoration.
Elucidating the exact mechanisms of EMF actions upon
microglia and astrocytes, and its role in neurorestoration
could be a key step in further research of the therapeutic
potential of EMFs in various neurological disorders.
Ključne riječi
Hrčak ID:
239738
URI
Datum izdavanja:
15.4.2019.
Posjeta: 580 *