Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2019.60.191
Multiple genetic analyses to investigate the polymorphisms of Chinese Mongolian population with an efficient short tandem repeat panel
Yating Fang
; School of Forensic Medicine, Southern Medical University, Guangzhou, China
Tong Xie
; School of Forensic Medicine, Southern Medical University, Guangzhou, China
Qiong Lan
; School of Forensic Medicine, Southern Medical University, Guangzhou, China
Xiaoye Jin
; Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an, China
Yongsong Zhou
; School of Forensic Medicine, Southern Medical University, Guangzhou, China
Jiangwei Yan
; CAS Key Laboratory of Genome Sciences and Information, BeijingInstitute of Genomics, ChineseAcademy of Sciences, Beijing, China
Bofeng Zhu
; School of Forensic Medicine, Southern Medical University, Guangzhou, China
Sažetak
Aim To determine allele frequencies and forensic statistics
of 22 autosomal short tandem repeat loci in Chinese Mongolian
population.
Methods Blood specimens were collected from 134 unrelated
healthy Mongolian individuals, and 22 short tandem
repeat loci were co-amplified and genotyped. Allele
frequencies and forensic parameters were calculated,
and population genetic differences were analyzed among
Mongolian population and other eight Chinese populations:
Northern Han, Guangdong Han, Chengdu Han, Xinjiang
Hui, Xinjiang Uygur, Hainan Li, Qinghai Tibetan, and
Hainan Han. Results All the loci were in the Hardy-Weinberg equilibrium,
and after Bonferroni correction there was no linkage
disequilibrium between them. The allele frequencies of
these 22 loci were between 0.0037 and 0.3657. This panel
had high discriminating power and genetic polymorphism
in the Mongolian population, with combined power of discrimination
of 0.999999999999999999999999998399 and
combined probability of exclusion of 0.9999999999566925.
Structure analysis showed no evidence that these nine Chinese
populations had different component distribution.
However, genetic distance analysis showed significant differences
among them (P < 0.05). Conclusion The combined application of these 22 loci
could be useful for forensic purposes in the Mongolian
population. Mongolian population had smaller genetic
distances from the populations in northern China (Northern
Han, Xinjiang Uygur, and Xinjiang Hui) than from the
populations in Hainan province (Hainan Han and Hainan
Li populations).
Ključne riječi
Hrčak ID:
240027
URI
Datum izdavanja:
15.6.2019.
Posjeta: 548 *