Skoči na glavni sadržaj

Croatian Medical Journal, Vol. 60 No. 5, 2019.

Izvorni znanstveni članak

https://doi.org/10.3325/cmj.2019.60.405

Serum ferritin levels and irregular use of iron chelators predict liver iron load in patients with major beta thalassemia: a cross-sectional study

Soheila Sobhani ; Students’ Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
Farzaneh Rahmani ; Students’ Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
Maryam Rahmani ; Students’ Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
Marzieh Askari ; Devision of Hematology and Oncology, Children’s Medical Center, Pediatric Center ofExcellence, Tehran University ofMedical Sciences, Tehran, Iran
Farzad Kompani ; Devision of Hematology and Oncology, Children’s Medical Center, Pediatric Center ofExcellence, Tehran University ofMedical Sciences, Tehran, Iran

Puni tekst: engleski pdf 154 Kb

str. 405-413

preuzimanja: 487

citiraj

Sažetak

Aim To determine whether serum ferritin, liver transaminases,
and regularity and type of iron chelation protocol
can be used to predict liver iron load as assessed by T2*
magnetic resonance imaging (MRI) in patients with beta
thalassemia major (TM).
Methods This cross-sectional study, conducted from
March 1, 2014 to March 1, 2015, involved 90 patients with
beta TM on regular packed red blood cell transfusion. Liver
and cardiac iron load were evaluated with T2* MRI. Compliance
with iron-chelating agents, deferoxamine or deferasirox,
and regularity of their use, as well as serum ferritin
and liver transaminase levels were assessed.Results Patients with high serum ferritin were 2.068 times
(95% confidence interval 1.26-3.37) more likely to have
higher liver or cardiac iron load. High serum aspartate aminotransferases
and irregular use of iron chelating agents,
but not their type, predicted higher cardiac iron load. In a
multiple regression model, serum ferritin level was the only
significant predictor of liver and myocardial iron load.
Conclusions Higher serum ferritin strongly predicted the
severity of cardiac and liver iron load. Irregular use of chelator
drugs was associated with a higher risk of cardiac and
liver iron load, regardless of the type of chelating agent.

Ključne riječi

Hrčak ID:

240104

URI

https://hrcak.srce.hr/240104

Datum izdavanja:

15.10.2019.

Posjeta: 926 *