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https://doi.org/10.3325/cmj.2019.60.421

Association of JAG1 gene polymorphism with systemic blood pressure in patients with obstructive sleep apnea: a prospective cohort study

Ivana Paraničová ; Department of Pneumology and Phtiseology, Medical Faculty of P.J. Šafárik University and L. PasteurUniversity Hospital, Košice, Slovakia
Viera Habalová ; Department of Medical Biology Medical Faculty of P. J. Šafárik University, Košice, Slovakia
Lucia Klimčáková ; Department of Medical Biology Medical Faculty of P. J. Šafárik University, Košice, Slovakia
Ivana Trojová ; Department of Pneumology and Phtiseology, Medical Faculty of P.J. Šafárik University and L. PasteurUniversity Hospital, Košice, Slovakia
Jozef Židzik ; Department of Medical Biology Medical Faculty of P. J. Šafárik University, Košice, Slovakia
Ivan Tkáč ; Department of Internal Medicine Medical Faculty of P. J. Šafárik University and L. Pasteur University Hospital, Košice, Slovakia
Ružena Tkáčová ; Department of Pneumology and Phtiseology, Medical Faculty of P.J. Šafárik University and L. PasteurUniversity Hospital, Košice, Slovakia
Pavol Joppa orcid id orcid.org/0000-0001-5055-0682 ; Department of Pneumology and Phtiseology, Medical Faculty of P.J. Šafárik University and L. PasteurUniversity Hospital, Košice, Slovakia


Puni tekst: engleski pdf 285 Kb

str. 421-430

preuzimanja: 280

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Sažetak

Aim To assess the effects of single nucleotide polymorphisms
(SNPs) on blood pressure control in patients with
obstructive sleep apnea (OSA).
Methods This prospective observational cohort study,
conducted between 2004 and 2014, examined the associations
of SNPs of JAG1, GUCY1A3-GUCY1B3, SH2B3, and
NPR3-C5orf23 genes with systolic and diastolic blood pressure
(SBP, DBP) in 1179 adults evaluated for OSA with overnight
polysomnography. Genotyping was performed by
unlabeled probe melting analysis.Results The patients were predominantly male (69.6%,
mean age 52 ± 11 years, apnea-hypopnea index 34 ± 31
episodes/h). Only JAG1 genotype was associated with SBP
and DBP: compared with AA homozygotes, G allele carriers
(pooled GG and AG genotype) had significantly higher
morning SBP (132 ± 19 vs 129 ± 18 mm Hg; P = 0.009)
and morning and evening DBP (85 ± 11 vs 83 ± 10 mm Hg,
P = 0.004; 86 ± 10 vs 84 ± 10 mm Hg, P = 0.012, respectively);
the differences remained significant after the correction
for multiple SNPs testing. In multivariate analyses, oxygen
desaturation index and JAG1 genotype independently
predicted morning SBP (P = 0.001, P = 0.003, respectively)
and DBP (P < 0.001, P = 0.005, respectively), and evening
SBP (P = 0.019, P = 0.048, respectively) and DBP (P = 0.018,
P = 0.018, respectively).
Conclusion This is the first replication study of the SNPs
recently linked to arterial hypertension in general population
by genome-wide association studies. Our findings
suggest that JAG1 genotype is related to blood pressure
control in OSA: G allele was associated with higher morning
and evening SBP and DBP.

Ključne riječi

Hrčak ID:

240106

URI

https://hrcak.srce.hr/240106

Datum izdavanja:

15.10.2019.

Posjeta: 648 *