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Croatian Medical Journal, Vol. 60 No. 5, 2019.

Izvorni znanstveni članak

https://doi.org/10.3325/cmj.2019.60.449

Stress echocardiography for left ventricular diastolic dysfunction detection in patients with non-severe chronic obstructive pulmonary disease: a cross-sectional study

Radostina Vl. Cherneva ; University Hospital for Respiratory Diseases “St. Sophia,” Sofia, Bulgaria
Mariana V. Gospodinova ; University Hospital of the Ministry of Internal Affairs, Sofia, Bulgaria
Stefan V. Denchev ; University Hospital of the Ministry of Internal Affairs, Sofia, Bulgaria
Rosen B. Petkov ; University Hospital for Respiratory Diseases “St. Sophia,” Sofia, Bulgaria
Dimitar E. Kostadinov ; University Hospital for Respiratory Diseases “St. Sophia,” Sofia, Bulgaria
Zheina Vl. Cherneva ; University Hospital of the Ministry of Internal Affairs, Sofia, Bulgaria

Puni tekst: engleski pdf 245 Kb

str. 449-457

preuzimanja: 229

citiraj

Sažetak

Aim To assess whether the simultaneous performance of
exercise stress echocardiography and cardio-pulmonary
testing (ESE-CPET) may facilitate the timely diagnosis of
subclinical left ventricular diastolic dysfunction (LVDD) in
patients with non-severe chronic obstructive pulmonary
disease (COPD), preserved left ventricular systolic function,
and exertional dyspnea or exercise intolerance.
Methods This cross-sectional study, conducted between
May 2017 and April 2018, involved 104 non-severe COPD
patients with exertional dyspnea and preserved ejection
fraction who underwent echocardiography before CPET
and 1-2 minutes after peak exercise. Based on the peak
E/e’ ratio, patients were divided into the group with stressinduced
LVDD – E/e’>15 and the group without stress-induced
LVDD. We assessed the association between LVDD
and the following CPET variables: minute ventilation, peak
oxygen uptake (VO2), ventilatory efficiency, heart rate reserve,
and blood pressure.Results During ESE-CPET, stress-induced LVDD occurred
in 67/104 patients (64%). These patients had lower work
load, peak VO2, O2 pulse, and minute ventilation (VE), and
higher VE/VCO2 slope than patients without stress-induced
LVDD (35.18 ± 10.4 vs 37.01 ± 11.11, P < 0.05). None of the
CPET variables correlated with E/e’.
Conclusion Combined ESE-CPET may distinguish masked
LVDD in patients with non-severe COPD with exertional
dyspnea and preserved left ventricular systolic function.
None of the CPET variables was a predictor for subclinical
LVDD.

Ključne riječi

Hrčak ID:

240109

URI

https://hrcak.srce.hr/240109

Datum izdavanja:

15.10.2019.

Posjeta: 604 *