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https://doi.org/10.20471/LO.2020.48.01.04

Androgenski receptori: nejasan sveprisutan mehanizam ili ključ koji nedostaje u trostruko negativnom raku dojke?

Ana Tečić-Vuger   ORCID icon orcid.org/0000-0003-2203-161X ; Medical Oncology Department, Division for Radiotherapy and Medical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Robert Šeparović   ORCID icon orcid.org/0000-0002-4002-2699 ; Medical Oncology Department, Division for Radiotherapy and Medical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; Medical School, University of Juraj Dobrila, Pula, Croatia
Ljubica Vazdar ; Medical Oncology Department, Division for Radiotherapy and Medical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Mirjana Pavlović ; Medical Oncology Department, Division for Radiotherapy and Medical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Petra Lepetić ; Medical Oncology Department, Division for Radiotherapy and Medical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Sanda Šitić ; Department of Oncological Pathology and Clinical Cytology, 'Ljudevit Jurak' University Department of Pathology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Božena Šarčević ; School of Medicine, University of Zagreb, Zagreb, Croatia
Damir Vrbanec ; Medical School, University of Juraj Dobrila, Pula, Croatia

Puni tekst: engleski, pdf (385 KB) str. 20-26 preuzimanja: 131* citiraj
APA 6th Edition
Tečić-Vuger, A., Šeparović, R., Vazdar, Lj., Pavlović, M., Lepetić, P., Šitić, S., ... Vrbanec, D. (2020). Androgen receptors: unclear ubiquitious mechanism or the missing key in the triple–negative breast cancer?. Libri Oncologici, 48 (1), 20-26. https://doi.org/10.20471/LO.2020.48.01.04
MLA 8th Edition
Tečić-Vuger, Ana, et al. "Androgen receptors: unclear ubiquitious mechanism or the missing key in the triple–negative breast cancer?." Libri Oncologici, vol. 48, br. 1, 2020, str. 20-26. https://doi.org/10.20471/LO.2020.48.01.04. Citirano 24.06.2021.
Chicago 17th Edition
Tečić-Vuger, Ana, Robert Šeparović, Ljubica Vazdar, Mirjana Pavlović, Petra Lepetić, Sanda Šitić, Božena Šarčević i Damir Vrbanec. "Androgen receptors: unclear ubiquitious mechanism or the missing key in the triple–negative breast cancer?." Libri Oncologici 48, br. 1 (2020): 20-26. https://doi.org/10.20471/LO.2020.48.01.04
Harvard
Tečić-Vuger, A., et al. (2020). 'Androgen receptors: unclear ubiquitious mechanism or the missing key in the triple–negative breast cancer?', Libri Oncologici, 48(1), str. 20-26. https://doi.org/10.20471/LO.2020.48.01.04
Vancouver
Tečić-Vuger A, Šeparović R, Vazdar Lj, Pavlović M, Lepetić P, Šitić S i sur. Androgen receptors: unclear ubiquitious mechanism or the missing key in the triple–negative breast cancer?. Libri Oncologici [Internet]. 2020 [pristupljeno 24.06.2021.];48(1):20-26. https://doi.org/10.20471/LO.2020.48.01.04
IEEE
A. Tečić-Vuger, et al., "Androgen receptors: unclear ubiquitious mechanism or the missing key in the triple–negative breast cancer?", Libri Oncologici, vol.48, br. 1, str. 20-26, 2020. [Online]. https://doi.org/10.20471/LO.2020.48.01.04

Sažetak
Androgenski receptori (AR) su jezgrini prepisivački čimbenici ovisni o ligandu. To su steroidni receptori, slični estrogenskim receptorima (ER). Izraženi su u brojnim stanicama s različitim gradivnim ulogama. AR signalizacija može biti uključena u razvoj različitih zloćudnih tumora, poput raka prostate, mokraćnog mjehura, jetre, žlijezda slinovnica, bubrega, pluća, melanoma, sarkoma, raka dojke i mnogih drugih. Uloga AR najjasnija je i najbolje objašnjena u raku prostate. Mehanizam AR signalizacije u drugim humanim epitelnim tumorima još je uvijek nejasan i učinci su kod različitih tumora različiti, sve do potpuno oprečnih. U raku dojke AR su najčešće izraženi receptori, ali još uvijek s nepotpuno jasnom ulogom, prognostičkim i prediktivnim značajem. Izraženost AR u trostruko negativnom raku dojke (TNBC) vrlo je varijabilna. Unatoč izraženim razlikama u rezultatima različitih analiza, čini se da blagotvorno utječu na prognozu i potencijalna su meta antihormonske terapije za liječenje TNRD u budućnosti.

Ključne riječi
androgenski receptori; rak prostate; rak dojke; trostruko negativni rak dojke

Hrčak ID: 240534

URI
https://hrcak.srce.hr/240534

[engleski]

Posjeta: 372 *