Infektološki glasnik, Vol. 39 No. 3, 2019.
Izvorni znanstveni članak
https://doi.org/10.37797/ig.39.3.1
Changes in the stage of fibrosis and steatosis in patients with chronic hepatitis C virus treated with direct-acting antiviral drugs who achieved sustained virological response
Leona Radmanić
orcid.org/0000-0001-9362-7213
; Klinika za infektivne bolesti “Dr. Fran Mihaljević”, Zagreb
Neven Papić
; Klinika za infektivne bolesti “Dr. Fran Mihaljević”, Zagreb; Medicinski fakultet, Sveučilište u Zagrebu
Ivan Kurelac
; Klinika za infektivne bolesti “Dr. Fran Mihaljević”, Zagreb
Davorka Dušek
; Klinika za infektivne bolesti “Dr. Fran Mihaljević”, Zagreb; Medicinski fakultet, Sveučilište u Zagrebu
Snježana Židovec Lepej
; Klinika za infektivne bolesti “Dr. Fran Mihaljević”, Zagreb
Adriana Vince
; Klinika za infektivne bolesti “Dr. Fran Mihaljević”, Zagreb; Medicinski fakultet, Sveučilište u Zagrebu
Sažetak
Hepatitis C is the leading cause of chronic liver disease, hepatocellular carcinoma and an important indication for liver transplantation. The main objective of the treatment is to achieve a sustained virological response defined as a negative HCV RNA 12 weeks after completion of therapy (SVR). Direct-acting antivirals have been developed to treat chronic HCV infection. They have resulted in increased SVR rates, shorter and simpler treatment regimens, and minimal adverse effects. The aim of this study was to analyze the change in the stage of fibrosis (F1-F4) and steatosis (S0-S3) using transient elastography in treating naive patients with chronic hepatitis C (n = 205) who achieved a sustained virological response and were treated exclusively with directly acting antiviral drugs (DAA).
Ključne riječi
chronic hepatitis C; fibrosis; steatosis; sustained virological response; direct-acting antiviral drugs
Hrčak ID:
240584
URI
Datum izdavanja:
5.7.2020.
Posjeta: 2.413 *