Veterinarski arhiv, Vol. 90 No. 3, 2020.
Izvorni znanstveni članak
https://doi.org/10.24099/vet.arhiv.0865
The antioxidant effect of the novel bee-product based intramammary formulation Apimast® in dairy cattle
Jelena Šuran
; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Jasna Aladrović
; Department of Physiology and Radiobiology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Blanka Beer Ljubić
; Clinic for Internal Diseases, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Josipa Vlainić
; Division of Molecular Medicine, Institute Ruđer Bošković, Zagreb, Croatia
Marija Mamić
; Clinic for Surgery, Orthopaedics and Ophthalmology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Božo Radić
; Hedera Ltd., Split, Croatia
Goran Bačić
; Clinic for Reproduction and Obstetrics, Faculty of Veterinary Medicine, University of Zagreb, Croatia
Nino Maćešić
; Clinic for Reproduction and Obstetrics, Faculty of Veterinary Medicine, University of Zagreb, Croatia
Miroslav Benić
; Department for Bacteriology and Parasitology, Croatian Veterinary Institue, Zagreb, Croatia
Antun Kostelić
; Department of Animal Science, Faculty of Agriculture, University of Zagreb, Croatia
Frane Božić
; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Hrvoje Pavasović
; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Lada Radin
; Department of Physiology and Radiobiology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Sažetak
The aim of this study was to determine the antioxidant effect of the novel bee-product based intramammary formulation Apimast® on the oxidative status of dairy cows. Apimast® was administered intramammarily three times at 12 h intervals to 10 dairy cows on each of the three dairy farms. The oxidative status markers and some metabolic parameters were determined in the milk (GSH-Px, d-ROM, SOD, BAP, TAS) and in the serum (SOD, GSH-Px, NEFA, BHB, glucose). The results showed that the effect of Apimast® was mostly local, regardless of the concentration used (3% and 1%) as there was an increase in the concentration of GSH-Px and TAS in the milk, but not in the blood. It is also of a short-term nature since the values of these parameters were significantly lower 7 days after application. The expected connection between the increase of ROM in milk samples from the microbiologically positive quarters was not found. The results of this study confirm the local antioxidant effect of Apimast® in the udder, with implications for non-antibiotic subclinical mastitis treatment.
Ključne riječi
mastitis; oxidative stress; Apimast®; propolis; dairy cows
Hrčak ID:
241731
URI
Datum izdavanja:
22.7.2020.
Posjeta: 939 *