Veterinarski arhiv, Vol. 90 No. 3, 2020.
Izvorni znanstveni članak
https://doi.org/10.24099/vet.arhiv.0657
Expression profile of growth hormone receptor (GHR), insulin like growth factor receptor (IGFR) and leptin genes, with associated blood bio-chemicals and endocrines profiles in black Bengal kids (Capra hircus) during different stages of pre-pubertal growth
Shagufta Perveen
; Department of Veterinary Physiology, West Bengal University of Animal and Fishery Sciences, K. B. Sarani, Kolkata, West Bengal, India
Pradip K. Das
; Department of Veterinary Physiology, West Bengal University of Animal and Fishery Sciences, K. B. Sarani, Kolkata, West Bengal, India
Prabal R. Ghosh
; Department of Veterinary Physiology, West Bengal University of Animal and Fishery Sciences, K. B. Sarani, Kolkata, West Bengal, India
Dipak Banerjee
; Department of Veterinary Physiology, West Bengal University of Animal and Fishery Sciences, K. B. Sarani, Kolkata, West Bengal, India
Joydip Mukherjee
; Department of Veterinary Physiology, West Bengal University of Animal and Fishery Sciences, K. B. Sarani, Kolkata, West Bengal, India
Mohan Mondal
; ICAR-National Dairy Research Institute (ERS), Kalyani, Nadia, India
Sažetak
The aim of this study was to evaluate the expression profile of growth hormone receptor (GHR), insulin like growth factor receptor (IGFR) and leptin genes, together with some blood biochemical (glucose, aspartate aminotransferase, AST; alanine aminotransferase, ALT) and endocrine (growth hormone and cortisol) parameters. For this purpose, blood samples were collected from 25 male and 25 female kids of the Black Bengal goat (Capra hircus), at days 15, 30, 60, 90, 120 and 150. Male kids gained more body weight compared to females. The glucose and cortisol levels significantly (P≤0.01) decreased with the advancement of age. AST, ALT, and growth hormone increased significantly (P≤0.01). In both sexes, plasma glucose level was negatively (P≤0.01) correlated with AST. In males both cortisol and GH levels were positively (P≤0.05) correlated with plasma glucose levels. In female kids only GH showed a positive (P≤0.05) correlation with glucose levels. Female kids had greater expression of the GH receptor, IGFR mRNA and Leptin mRNA on day 30 (P≤0.05) and day 150 (P≤0.01). GHR was only positively (P≤0.05) correlated with IGFR and LEP in female kids. On the basis of the results obtained from our research, we are able to conclude that the lower growth rate in female kids expressed more leptin, which stimulated the somatotrophic axis for the expression of GHR and IGFR during the prepubertal growth stage.
Ključne riječi
black Bengal goats; growth hormone receptor; IGF receptor; leptin genes; prepubertal growth
Hrčak ID:
241820
URI
Datum izdavanja:
22.7.2020.
Posjeta: 947 *