Acta clinica Croatica, Vol. 59. No. 1., 2020.
Izvorni znanstveni članak
https://doi.org/10.20471/acc.2020.59.01.03
Serum Bilirubin Correlates with Serum Adipokines in Normal Weight and Overweight Asymptomatic Adults
Ana Petelin
; Faculty of Health Sciences, University of Primorska, Izola, Slovenia
Mihaela Jurdana
; Faculty of Health Sciences, University of Primorska, Izola, Slovenia
Zala Jenko Pražnikar
; Faculty of Health Sciences, University of Primorska, Izola, Slovenia
Lovro Žiberna
orcid.org/0000-0002-2840-5208
; Institute of Pharmacology and Experimental Toxicology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
Sažetak
Overweight and obesity are considered as chronic low-grade inflammation accompanied by imbalanced production of adipokines. The aim of this study was to elucidate the relationship between serum bilirubin, which is an endogenous antioxidant with anti-inflammatory
activity, and pro- and anti-inflammatory serum adipokines in asymptomatic normal weight and overweight individuals. Healthy men and women aged 25-49 participated in this cross-sectional study. All participants underwent fasting serological measurements of adipokines, interleukin-6, tumor necrosis factor alpha (TNF-α), C-reactive protein (CRP), total and direct serum bilirubin, and other biochemical parameters. Participants were divided into normal weight and overweight groups. We found a significant negative association between total bilirubin and CRP, TNF-α, visfatin and resistin values, and a significant positive association between total bilirubin and adiponectin values in both normal weight and overweight groups. Importantly, after adjusting for body mass index, we also found a significant negative association between total serum bilirubin levels and both visfatin and
CRP serum levels. Moreover, visfatin, resistin and CRP were predictors of the total serum bilirubin levels.
Ključne riječi
Adipokines; Bilirubin; C-reactive protein; Overweight; Obesity; Cross-sectional studies
Hrčak ID:
242192
URI
Datum izdavanja:
1.3.2020.
Posjeta: 1.333 *