Izvorni znanstveni članak

https://doi.org/10.20471/acc.2020.59.01.11

Relationship between Insulin-Like Growth Factor Type 1 and Intrauterine Growth

Lidija Banjac orcid.org/0000-0003-0567-041X ; Department of Neonatology, Clinical Center of Montenegro, Podgorica, Montenegro
Jelena Kotur-Stevuljevic orcid.org/0000-0002-6980-3069 ; Institute of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
Tamara Gojković ; Institute of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
Vesna Bokan-Mirkovic ; Center for Physical Medicine and Rehabilitation, Clinical Center of Montenegro, Podgorica, Montenegro
Goran Banjac ; Institute of Children’s Diseases, Clinical Center of Montenegro, Podgorica, Montenegro
Gorica Banjac ; e Obstetrics and Gynaecology Clinic Narodni Front, Belgrade, Serbia

Sažetak

Insulin-like growth factor 1 (IGF-1) is a regulator of intrauterine growth, and circulating concentrations are reduced in intrauterine growth-restricted fetuses. The aim of our study was to investigate the relationship between IGF-1 levels in newborns and intrauterine growth,
expressed as birth weight (BW). The research was designed as a cross-sectional study. The study included 71 premature newborns, gestational age (GA) ≤33 weeks. Quantitative determination of IGF-1 was performed in the 33rd post-menstrual week (pmw) to make the measurements more comparable. We used an enzyme-bound immunosorbent test for quantitative determination of IGF-1. Our results showed the mean IGF-1 level in premature newborns in 33rd pmw to be 23.1±4.56 (range 15.44-39.75) μg/L. There was no difference in IGF-1 values between male (23.1±4.98 μg/L) and female (23.1±4.87 μg/L) newborns. Tere was no significant difference in the average IGF-1
levels between male and female newborns with BW <50th and BW >50th percentile for GA either (p>0.50). Only BW <33rd percentile newborns had a statistically significantly lower IGF-1 level compared
to newborns with greater BW. Based on our results, it is concluded that serum IGF-1 level reflects intrauterine growth only in BW <33rd percentile newborns. This fact could be used for further therapeutic purposes.

Ključne riječi

Infant, newborn; Insulin-like growth factor I; Fetal growth retardation; Cross-sectional studies

Hrčak ID:

242281

URI

https://hrcak.srce.hr/242281

Datum izdavanja:

1.3.2020.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.168 *