Skoči na glavni sadržaj

Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti, No. 499=32, 2008.

Pregledni rad

Cyclodextrin-based pharmaceutical

Mario Jug orcid id orcid.org/0000-0002-7473-9807 ; Farmaceutsko biokemijski fakultet Sveučilišta u Zagreb, Zagreb, Hrvatska
Mira Bećirević-Laćan

Puni tekst: engleski pdf 315 Kb

str. 9-26

preuzimanja: 1.611

citiraj

Sažetak

Cyclodextrins, cyclic oligosacharides, are useful pharmaceutical excipients, which have attracted widespread attention. The ground for their popularity from a pharmaceutical point of view is in their ability to change undesirable characteristics of the drugs, such as unpleasant taste, low aqueous solubility, chemical instability and improving the drug bioavailability by inclusion complex formation. Due to their biocompatibility, cyclodextrins may be used in formulations indented for different routes of drug application including oral, ocular, nasal and even parenteral route. This article outlines the importance and functionality of cyclodextrin in different dosage forms and indicates the possible directions of future development.

Ključne riječi

ciklodekstrin; inkluzijski kompleks; primjena lijeka; topljivost u vodi; kemijska stabilnost; bioraspoloživost

Hrčak ID:

22473

URI

https://hrcak.srce.hr/22473

Datum izdavanja:

21.4.2008.

Podaci na drugim jezicima: hrvatski

Posjeta: 3.528 *