Croatica Chemica Acta, Vol. 29 No. 3-4, 1957.
Izvorni znanstveni članak
Application of the Asymmetric Synthesis in the Determination of the Configuration of Amino Alcohols and Diamines with Two Adjacent Asymmetric Carbon Atoms
M. Proštenik
; Department of Chemistry, Faculty of Medicine, University of Zagreb , Zagreb, Croatia, Yugoslavia
P. Alaupović
; Department of Chemistry, Faculty of Medicine, University of Zagreb , Zagreb, Croatia, Yugoslavia
Sažetak
Optically active a-amino ketones of known configuration (D-) can be prepared by virtue of the Bowman ketone synthesis starting with optically active, natural a-amino acids as acylating components. By reduction of a-amino ketones and of their oximes with lithium aluminum ,hydride the hydroxy and the second amino group were induced asymmetrically yielding in both cases predominantly the erythro epimers of corresponding a- amino alcohols and a-diamines. This is in agreement with Cram's rule of the steric control of the asymmetric induction.
Ključne riječi
Hrčak ID:
246319
URI
Datum izdavanja:
30.12.1957.
Posjeta: 382 *