Izvorni znanstveni članak
The Role of Endothelin-1 and Nitric Oxide in the Pathogenesis of Hypertension in Diabetic Patients
Monika Tomić
Krešimir Galešić
Jadranka Morović-Vergles
Željko Romić
Ivanka Mikulić
Sažetak
The pathogenesis of renal hypertension has not yet been fully clarified. As the potential role of endothelin-1 (ET-1) and
nitric oxide (NO) has been postulated, their concentrations were determined in plasma and urine of diabetic patients.
The study included 30 diabetic patients (both IDDM and NIDDM) with initial or advanced diabetic nephropathy (decreased
endogenous creatinine clearance, proteinuria) and 20 healthy control subjects. The correlation with blood pressure
and other renal function parameters was monitored and compared with the control group. Also, the effect of ACE inhibitors
(ACEI) on ET-1 and NO patterns was monitored in correlation with arterial hypertension. In diabetic patients
that did not receive ACEI therapy, the increase in plasma ET-1 was associated with both systolic and diastolic blood pressure
elevation, whereas in those administered ACEI the increase in plasma ET-1 was associated with a systolic blood
pressure decline. In addition, the increase in plasma NO was accompanied by a statistically significant decline of both
systolic and diastolic blood pressure in diabetic patients receiving ACEI.
Ključne riječi
endothelin-1; nitric oxide; diabetes mellitus; hypertension
Hrčak ID:
22819
URI
Datum izdavanja:
8.5.2008.
Posjeta: 883 *