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The Effect of a Single Dose of Fumonisin B1 on Rat Kidney

Maja Peraica ; Institute for Medical Research and Occupational Health, Zagreb, Croatia
Danica Ljubanović ; Clinical Hospital Dubrava, Zagreb, Croatia
Davor Želježić ; Institute for Medical Research and Occupational Health, Zagreb, Croatia
Ana-Marija Domijan ; Institute for Medical Research and Occupational Health, Zagreb, Croatia

Puni tekst: engleski, pdf (161 KB) str. 119-124 preuzimanja: 437* citiraj
APA 6th Edition
Peraica, M., Ljubanović, D., Želježić, D. i Domijan, A. (2008). The Effect of a Single Dose of Fumonisin B1 on Rat Kidney. Croatica Chemica Acta, 81 (1), 119-124. Preuzeto s https://hrcak.srce.hr/23426
MLA 8th Edition
Peraica, Maja, et al. "The Effect of a Single Dose of Fumonisin B1 on Rat Kidney." Croatica Chemica Acta, vol. 81, br. 1, 2008, str. 119-124. https://hrcak.srce.hr/23426. Citirano 08.03.2021.
Chicago 17th Edition
Peraica, Maja, Danica Ljubanović, Davor Želježić i Ana-Marija Domijan. "The Effect of a Single Dose of Fumonisin B1 on Rat Kidney." Croatica Chemica Acta 81, br. 1 (2008): 119-124. https://hrcak.srce.hr/23426
Harvard
Peraica, M., et al. (2008). 'The Effect of a Single Dose of Fumonisin B1 on Rat Kidney', Croatica Chemica Acta, 81(1), str. 119-124. Preuzeto s: https://hrcak.srce.hr/23426 (Datum pristupa: 08.03.2021.)
Vancouver
Peraica M, Ljubanović D, Želježić D, Domijan A. The Effect of a Single Dose of Fumonisin B1 on Rat Kidney. Croatica Chemica Acta [Internet]. 2008 [pristupljeno 08.03.2021.];81(1):119-124. Dostupno na: https://hrcak.srce.hr/23426
IEEE
M. Peraica, D. Ljubanović, D. Želježić i A. Domijan, "The Effect of a Single Dose of Fumonisin B1 on Rat Kidney", Croatica Chemica Acta, vol.81, br. 1, str. 119-124, 2008. [Online]. Dostupno na: https://hrcak.srce.hr/23426. [Citirano: 08.03.2021.]

Sažetak
It is known that exposure to mycotoxin fumonisin B1 (FB1) causes apoptosis and increases lipid peroxidation in the kidney of experimental animals. In this study, adult male Wistar rats were given a single dose (5, 50, 500 mg per kg of body mass) by gavage and sacrificed 4, 24 and 48 hours after dosing. The parameters of oxidative stress, sphingolipids, DNA lesions and histopathological changes were checked in the kidney of treated and control animals. The metabolism of sphingolipids was significantly affected with the lowest FB1 dose (sphinganine/sphingosine: 2.53 ± 0.52 vs. control 0.62 ± 0.10), while even the highest dose did not change the parameters of oxidative stress. DNA lesions measured as comet tail length (range (13.6 ± 0.41) mm to (19.83 ± 1.43) mm) and tail intensity ((0.60 ± 0.16) % to (2.74 ± 0.17) %) were FB1 dose- and time-dependent. Apoptotic cells and mitotic figures were found in the cortical and outer stripe of the medullar part of the kidney.

Ključne riječi
mycotoxin; comet assay; glutathione; oxidative stress; histopathology; sphingolipids

Hrčak ID: 23426

URI
https://hrcak.srce.hr/23426

Posjeta: 714 *