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Kinetic Evaluation of Imidacloprid Degradation in Mice Organs Treated with Olive Oil Polyphenols Extract

Dalibor Broznić ; School of Medicine, University of Rijeka, Rijeka, Croatia
Jelena Marinić ; School of Medicine, University of Rijeka, Rijeka, Croatia
Marin Tota ; School of Medicine, University of Rijeka, Rijeka, Croatia
Gordana Čanadi Jurešić ; School of Medicine, University of Rijeka, Rijeka, Croatia
Čedomila Milin ; School of Medicine, University of Rijeka, Rijeka, Croatia

Puni tekst: engleski, pdf (242 KB) str. 203-209 preuzimanja: 1.202* citiraj
APA 6th Edition
Broznić, D., Marinić, J., Tota, M., Čanadi Jurešić, G. i Milin, Č. (2008). Kinetic Evaluation of Imidacloprid Degradation in Mice Organs Treated with Olive Oil Polyphenols Extract. Croatica Chemica Acta, 81 (1), 203-209. Preuzeto s https://hrcak.srce.hr/23448
MLA 8th Edition
Broznić, Dalibor, et al. "Kinetic Evaluation of Imidacloprid Degradation in Mice Organs Treated with Olive Oil Polyphenols Extract." Croatica Chemica Acta, vol. 81, br. 1, 2008, str. 203-209. https://hrcak.srce.hr/23448. Citirano 20.07.2019.
Chicago 17th Edition
Broznić, Dalibor, Jelena Marinić, Marin Tota, Gordana Čanadi Jurešić i Čedomila Milin. "Kinetic Evaluation of Imidacloprid Degradation in Mice Organs Treated with Olive Oil Polyphenols Extract." Croatica Chemica Acta 81, br. 1 (2008): 203-209. https://hrcak.srce.hr/23448
Harvard
Broznić, D., et al. (2008). 'Kinetic Evaluation of Imidacloprid Degradation in Mice Organs Treated with Olive Oil Polyphenols Extract', Croatica Chemica Acta, 81(1), str. 203-209. Preuzeto s: https://hrcak.srce.hr/23448 (Datum pristupa: 20.07.2019.)
Vancouver
Broznić D, Marinić J, Tota M, Čanadi Jurešić G, Milin Č. Kinetic Evaluation of Imidacloprid Degradation in Mice Organs Treated with Olive Oil Polyphenols Extract. Croatica Chemica Acta [Internet]. 2008 [pristupljeno 20.07.2019.];81(1):203-209. Dostupno na: https://hrcak.srce.hr/23448
IEEE
D. Broznić, J. Marinić, M. Tota, G. Čanadi Jurešić i Č. Milin, "Kinetic Evaluation of Imidacloprid Degradation in Mice Organs Treated with Olive Oil Polyphenols Extract", Croatica Chemica Acta, vol.81, br. 1, str. 203-209, 2008. [Online]. Dostupno na: https://hrcak.srce.hr/23448. [Citirano: 20.07.2019.]

Sažetak
Imidacloprid is a highly effective insecticide, acting as agonists at the insect nicotinic acetylcholine receptor. Nevertheless, imidacloprid itself or its metabolites could exhibit toxicity in mammals. Imidacloprid biotransformation involves oxidative cleavage, releasing the 6-chloronicotinic acid. Therefore, the concentration of imidacloprid and 6-chloronicotinic acid was used to characterize degradation kinetics and distribution of imidacloprid in mice liver, kidneys and lungs. Additionally, the influence of olive oil polyphenols on imidacloprid metabolism was evaluated. Experimental animals were divided into three groups: control, IMI – imidacloprid treated mice (5 mg/kg) and (IMI + PP) – mice treated with polyphenols (10 mg/kg) for seven days before the administration of imidacloprid. Neither imidacloprid nor 6-chloronicotinic acid could be detected 48 hours after administration in IMI group, while complete degradation in the (IMI + PP) group was accomplished within 24 hours. Significantly higher rate constant and shorter half-life in (IMI + PP) group emphasize that polyphenols may diminish the toxicity of this pesticide.

Ključne riječi
imidacloprid; 6-chloronicotinic acid; degradation kinetics; polyphenols; olive oil

Hrčak ID: 23448

URI
https://hrcak.srce.hr/23448

Posjeta: 1.590 *