Izvorni znanstveni članak

https://doi.org/10.20471/acc.2021.60.01.08

The Role of Salivary and Serum Ca125 and Routine Blood Tests in Patients with Ovarian Malignancies

Ante Vuković orcid.org/0000-0003-2978-0584 ; Department of Gynecology and Obstetrics, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia
Krunoslav Kuna orcid.org/0000-0002-7119-0070 ; Department of Gynecology and Obstetrics, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia
Božana Lončar Brzak orcid.org/0000-0001-6096-6796
†Vanja Vučičević Boras ; Department of Oral Medicine, School of Dental Medicine, University of Zagreb, Zagreb, Croatia
Robert Šeparović ; University Hospital for Tumors, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia
Mario Šekerija orcid.org/0000-0001-7508-1501 ; Croatian Institute of Public Health, Zagreb, Croatia
Lada Šumilin orcid.org/0000-0002-1221-7923 ; Aviva Polyclinic, Zagreb, Croatia
Valentina Vidranski ; Department of Nuclear Medicine, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia

Sažetak

The use of routine blood tests has recently been shown to be promising in determining
disease-free and overall survival in patients with various malignancies, and also in gynecologic
malignancies. The aim of this study was to evaluate whether salivary and serum CA125 levels
correlate and whether salivary and serum CA125, C-reactive protein and routine blood tests might
serve as a prognostic factor in malignant ovarian tumors, and whether they might differentiate between
benign and malignant ovarian tumors. A total of 98 women were included (48 with benign
ovarian tumors and 50 with malignant ovarian tumors), in whom routine blood tests were made and
salivary and serum CA125 levels were determined by use of ELISA. Increase in serum CA125 and
amylase decreased overall survival, whereas increase in salivary CA125, potassium levels and hemoglobin
increased overall survival. Significant correlation of serum CA125 and C-reactive protein was
found in the group with malignant tumors. In conclusion, significant increase in the levels of serum
CA125 and amylase correlated with decreased survival, whereas increased salivary CA125, hemoglobin
and potassium levels significantly correlated with increased survival.

Ključne riječi

Malignancies; CA125 antigen; Blood tests

Hrčak ID:

259826

URI

https://hrcak.srce.hr/259826

Datum izdavanja:

1.3.2021.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.059 *