Izvorni znanstveni članak

https://doi.org/10.20471/acc.2021.60.01.09

Comparison of Real World Lipid Profile of Patients with Type 2 Diabetes and Guideline Recommendations

Mirac Vural Keskinler ; Istanbul Medeniyet University Goztepe Training and Research Hospital, Department of Internal Medicine, Istanbul, Turkey
Irem Bozkurt ; Istanbul Medeniyet University Goztepe Training and Research Hospital, Department of Internal Medicine, Istanbul, Turkey
Ozge Telci Caklili orcid.org/0000-0001-7566-5427 ; Istanbul University Faculty of Medicine, Department of Endocrinology and Metabolism, Istanbul, Turkey
Gunes Feyizoglu ; Istanbul Medeniyet University Goztepe Training and Research Hospital, Department of Internal Medicine, Istanbul, Turkey
Zeynep Gul ; Istanbul Medeniyet University Goztepe Training and Research Hospital, Department of Internal Medicine, Istanbul, Turkey
Asli Karsli ; Istanbul Medeniyet University Goztepe Training and Research Hospital, Department of Internal Medicine, Istanbul, Turkey
Aytekin Oguz ; Istanbul Medeniyet University Goztepe Training and Research Hospital, Department of Internal Medicine, Istanbul, Turkey

Sažetak

Diabetes is a major risk factor for cardiovascular disease. Despite recommendations
and available therapeutic options, patients with diabetes do not always reach the recommended lipid
levels. In this study, our aim was to compare the real world lipid profile of type 2 diabetes patients with
guideline recommendations for dyslipidemia. Four hundred and sixty eight consecutive patients referred
to Outpatient Diabetes Clinic of Istanbul Medeniyet University were recruited. Patient anthropometric
measurements (height, weight, waist circumference), biochemical test results (LDL cholesterol
(LDL-c), triglycerides, HDL cholesterol, HbA1c) and treatment modalities were recorded. Patients
were stratified into cardiovascular risk categories according to the risk factors and their treatment
dose was compared to the recommendations. Among 468 patients, 56 (12%) patients had coronary
heart disease (CHD). Thirty-four percent of these patients were not on statin treatment (n=19) and
their mean LDL-c level was 114±29 mg/dL (2.9±0.75 mmol/L). Nineteen percent of these patients
were on high intensity statin treatment (atorvastatin 40-80 mg, rosuvastatin 20 mg). Only four patients
with CHD had LDL-c levels <70 mg/dL (1.8 mmol/L). Four hundred and twelve patients had no
CHD. In these patients, the mean LDL-c level was 132±38 mg/dL (3.4±0.9 mmol/L). Eighty (19%)
patients had LDL-c level lower than 100 mg/dL (2.5 mmol/L). Overall 82% (n=384) of the cohort had
not achieved treatment goal. In conclusion, a more pronounced approach for statin treatment is needed
in diabetes patients for both primary and secondary prevention of cardiovascular diseases.

Ključne riječi

Type 2 diabetes; Dyslipidemia; Coronary heart disease

Hrčak ID:

259843

URI

https://hrcak.srce.hr/259843

Datum izdavanja:

1.3.2021.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.233 *