Pregledni rad

Molecular impact of glutathione peroxidases in antioxidant processes

Simona Jurkovič orcid.org/0000-0002-2552-456X ; Klinički zavod za kemiju i biokemiju, Sveučilišni medicinski centar„Ljubljana", Ljubljana, Slovenia
Joško Osredkar orcid.org/0000-0002-1839-2415 ; Klinički zavod za kemiju i biokemiju, Sveučilišni medicinski centar„Ljubljana", Ljubljana, Slovenia
Janja Marc orcid.org/0000-0001-6013-9758 ; Farmaceutski fakultet Sveučilišta u Ljubljani, Ljubljana, Slovenia

Sažetak

Reactive oxygen species (ROS) are produced during different pathological processes in increased concentrations. They cause lipid peroxidation and oxidation of DNA and proteins due to their high chemical reactivity. However, antioxidative defense mechanisms, including different antioxidant enzymes, prevent tissue damages and other ROS-related complications. The focus of this review is on effects of different glutathione peroxidases (GPXs) on molecular control of reactive oxygen species toxicology. Furthermore, specific biochemical properties, synthesis and role of each glutathione peroxidase isoenzyme in biological processes are described. Small molecules acting as mimetics of the active site of glutathione peroxidases could become new tools for treatment of many diseases.

Ključne riječi

antioxidant process; glutathione peroxidase; SECIS motif; glutathione; selenium; isoenzymes

Hrčak ID:

24139

URI

https://hrcak.srce.hr/24139

Datum izdavanja:

5.6.2008.

Podaci na drugim jezicima: hrvatski

Posjeta: 3.270 *