Acta clinica Croatica, Vol. 60. No. 2., 2021.
Izvorni znanstveni članak
https://doi.org/10.20471/acc.2021.60.02.14
Assessment of Allergies to Food and Additives in Patients with Angioedema, Burning Mouth Syndrome, Cheilitis, Gingivostomatitis, Oral Lichenoid Reactions, and Perioral Dermatitis
Iva Domić
; Department of Dermatovenereology, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia
Jozo Budimir
; Department of Dermatovenereology, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia
Ina Novak
; Department of Dermatovenereology, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia
Marinka Mravak-Stipetić
; School of Dental Medicine, University of Zagreb, Zagreb, Croatia
Liborija Lugović-Mihić
; Department of Dermatovenereology, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; School of Dental Medicine, University of Zagreb, Zagreb, Croatia
Sažetak
Oral cavity and perioral area are constantly exposed to a variety of antigens, including
food and additives, which have a potential role in the development of different oral mucosal
and perioral cutaneous diseases since they can cause hypersensitivity reactions. Oral and perioral diseases
mainly include angioedema, burning mouth syndrome, cheilitis, gingivostomatitis, oral lichenoid
reactions, and perioral dermatitis. Previous studies were focused on delayed-type oral allergies by
performing patch testing but did not include tests for immediate-type allergic reactions. Therefore, the
objective of this study was to determine common nutritive and additive allergens in the prevalent oral
and perioral diseases by using skin prick tests. Our study evaluated 230 participants, i.e. 180 patients
with oral/perioral diseases (angioedema, burning mouth syndrome, cheilitis, gingivostomatitis, oral
lichenoid reactions, and perioral dermatitis), and 50 healthy control subjects. The results of skin prick
tests showed that immediate-type allergic reactions to food and additives were mostly seen in patients
with burning mouth syndrome (40%) and cheilitis (33.3%), whereas allergies were least frequently
observed in perioral dermatitis (10%) and gingivostomatitis (20%). Fruits, mushrooms, and vegetables
were the most frequent causes of nutritive allergies in oral and perioral diseases. The most commonly
identified additive allergens were glutaraldehyde, citric acid, and sodium glutamate. Study results suggest
the possible association with nutritive and additive allergies be considered in cases of persistent
oral mucosal or perioral skin disease accompanied by respective medical history.
Ključne riječi
Additives; Allergy; Food; Oral diseases; Perioral diseases; Skin prick test; Patch test; Skin; Angioedema
Hrčak ID:
263708
URI
Datum izdavanja:
1.6.2021.
Posjeta: 1.385 *