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https://doi.org/10.2478/v10007-008-0012-5

Stability of amlodipine besylate and atenolol in multi-component tablets of mono-layer and bi-layer types

SAJJAN ARYAL ; Quest Pharmaceuticals (P) Ltd. Chhata Pipara, Bara, Nepal
NATAŠA ŠKALKO-BASNET ; The School of Pharmaceutical and Biomedical Sciences, Faculty of Science and Technology, Pokhara University, PO Box 427, Pokhara, Nepal

Fulltext: english, pdf (81 KB) pages 299-308 downloads: 4.384* cite
APA 6th Edition
ARYAL, S. & ŠKALKO-BASNET, N. (2008). Stability of amlodipine besylate and atenolol in multi-component tablets of mono-layer and bi-layer types. Acta Pharmaceutica, 58 (3), 299-308. https://doi.org/10.2478/v10007-008-0012-5
MLA 8th Edition
ARYAL, SAJJAN and NATAŠA ŠKALKO-BASNET. "Stability of amlodipine besylate and atenolol in multi-component tablets of mono-layer and bi-layer types." Acta Pharmaceutica, vol. 58, no. 3, 2008, pp. 299-308. https://doi.org/10.2478/v10007-008-0012-5. Accessed 24 Oct. 2019.
Chicago 17th Edition
ARYAL, SAJJAN and NATAŠA ŠKALKO-BASNET. "Stability of amlodipine besylate and atenolol in multi-component tablets of mono-layer and bi-layer types." Acta Pharmaceutica 58, no. 3 (2008): 299-308. https://doi.org/10.2478/v10007-008-0012-5
Harvard
ARYAL, S., and ŠKALKO-BASNET, N. (2008). 'Stability of amlodipine besylate and atenolol in multi-component tablets of mono-layer and bi-layer types', Acta Pharmaceutica, 58(3), pp. 299-308. https://doi.org/10.2478/v10007-008-0012-5
Vancouver
ARYAL S, ŠKALKO-BASNET N. Stability of amlodipine besylate and atenolol in multi-component tablets of mono-layer and bi-layer types. Acta Pharm. [Internet]. 2008 [cited 2019 October 24];58(3):299-308. https://doi.org/10.2478/v10007-008-0012-5
IEEE
S. ARYAL and N. ŠKALKO-BASNET, "Stability of amlodipine besylate and atenolol in multi-component tablets of mono-layer and bi-layer types", Acta Pharmaceutica, vol.58, no. 3, pp. 299-308, 2008. [Online]. https://doi.org/10.2478/v10007-008-0012-5

Abstracts
Multi-drug tablets of amlodipine besylate and atenolol were prepared as either mono-layer (mixed matrix) or bi-layer tablets containing each drug in a separate layer by using similar excipients and processing. Each tablet batch was packed in strip and blister packs and kept under accelerated temperature and humidity conditions. The stability of two tablet and packaging types was compared by HPLC analysis after 0, 1, 3 and 4.5 months and expressed as the content of intact amlodipine and atenolol.
The content of atenolol did not decline regardless of tablet and packaging type. Amlodipine content in bi-layer tablets decreased to about 95 and 88% when packed in strips and blisters, respectively. When prepared as mono-layer tablets, the content decreased to 72 and 32%, respectively.
The study revealed that the bi-layer tablet formulation was more stable than the mono-layer type. Further, the stability was increased when the tablets were packed in aluminium strips as compared to PVC blisters.

Keywords
amlodipine; atenolol; mono-layer; bi-layer tablet

Hrčak ID: 24510

URI
https://hrcak.srce.hr/24510

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