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Original scientific paper

Lithium Effect on Glutamate Induced Damage in Glioblastoma Cells

Sanjica Jakopec
Dalibor Karlović
Klara Dubravčić
Drago Batinić
Jasna Sorić
Anamaria Brozović
Danijel Buljan
Maja Osmak

Fulltext: english, pdf (106 KB) pages 87-91 downloads: 360* cite
APA 6th Edition
Jakopec, S., Karlović, D., Dubravčić, K., Batinić, D., Sorić, J., Brozović, A., ... Osmak, M. (2008). Lithium Effect on Glutamate Induced Damage in Glioblastoma Cells. Collegium antropologicum, 32 - Supplement 1 (1), 87-91. Retrieved from https://hrcak.srce.hr/24559
MLA 8th Edition
Jakopec, Sanjica, et al. "Lithium Effect on Glutamate Induced Damage in Glioblastoma Cells." Collegium antropologicum, vol. 32 - Supplement 1, no. 1, 2008, pp. 87-91. https://hrcak.srce.hr/24559. Accessed 3 Mar. 2021.
Chicago 17th Edition
Jakopec, Sanjica, Dalibor Karlović, Klara Dubravčić, Drago Batinić, Jasna Sorić, Anamaria Brozović, Danijel Buljan and Maja Osmak. "Lithium Effect on Glutamate Induced Damage in Glioblastoma Cells." Collegium antropologicum 32 - Supplement 1, no. 1 (2008): 87-91. https://hrcak.srce.hr/24559
Harvard
Jakopec, S., et al. (2008). 'Lithium Effect on Glutamate Induced Damage in Glioblastoma Cells', Collegium antropologicum, 32 - Supplement 1(1), pp. 87-91. Available at: https://hrcak.srce.hr/24559 (Accessed 03 March 2021)
Vancouver
Jakopec S, Karlović D, Dubravčić K, Batinić D, Sorić J, Brozović A, et al. Lithium Effect on Glutamate Induced Damage in Glioblastoma Cells. Collegium antropologicum [Internet]. 2008 [cited 2021 March 03];32 - Supplement 1(1):87-91. Available from: https://hrcak.srce.hr/24559
IEEE
S. Jakopec, et al., "Lithium Effect on Glutamate Induced Damage in Glioblastoma Cells", Collegium antropologicum, vol.32 - Supplement 1, no. 1, pp. 87-91, 2008. [Online]. Available: https://hrcak.srce.hr/24559. [Accessed: 03 March 2021]

Abstracts
Lithium, besides mood stabilization, might be involved in neuroprotection. Previously we have found that the treatment
with lithium increased the levels of p21WAF/Cip1 and survivin in human glioblastoma A1235 cells. The aim of the
present study was to examine the cytotoxic effect of glutamate on these cells, and to determine whether lithium can protect
A1235 cells against toxic effects of glutamate. Cytotoxicity of glutamate was examined by spectrophotometric MTT assay,
while the expression of apoptosis related genes was examined by Western blot method. Glutamate was excessively cytotoxic
for A1235 cells only in concentrations higher than 100 mM. It did not induce apoptosis, but rather suppressed
survivin expression and increased the level of p21WAF/Cip1. Pretreatment with lithium (2 mM) partially reverted change in
survivin expression induced by glutamate, suggesting that lithium may have beneficial effect on glutamate induced cell
damage in glioblastoma cells.

Keywords
glioblastoma cells; glutamate; lithium; survivin; p21WAF/Cip1

Hrčak ID: 24559

URI
https://hrcak.srce.hr/24559

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