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Increased Permeability of the Blood-Brain Barrier Following Administration of Glyceryl Trinitrate in Common Carp (Cyprinus carpio L.)

Sanja Kovačić
Zdravko Petrinec
Željka Matašin
Emil Gjurčević
Goran Ivkić
Arijana Lovrenčić-Huzjan
Maja Šegvić-Klarić
Lada Rumora
Stjepan Pepeljnjak

Puni tekst: engleski, pdf (182 KB) str. 99-103 preuzimanja: 659* citiraj
APA 6th Edition
Kovačić, S., Petrinec, Z., Matašin, Ž., Gjurčević, E., Ivkić, G., Lovrenčić-Huzjan, A., ... Pepeljnjak, S. (2008). Increased Permeability of the Blood-Brain Barrier Following Administration of Glyceryl Trinitrate in Common Carp (Cyprinus carpio L.). Collegium antropologicum, 32 - Supplement 1 (1), 99-103. Preuzeto s https://hrcak.srce.hr/24561
MLA 8th Edition
Kovačić, Sanja, et al. "Increased Permeability of the Blood-Brain Barrier Following Administration of Glyceryl Trinitrate in Common Carp (Cyprinus carpio L.)." Collegium antropologicum, vol. 32 - Supplement 1, br. 1, 2008, str. 99-103. https://hrcak.srce.hr/24561. Citirano 25.02.2020.
Chicago 17th Edition
Kovačić, Sanja, Zdravko Petrinec, Željka Matašin, Emil Gjurčević, Goran Ivkić, Arijana Lovrenčić-Huzjan, Maja Šegvić-Klarić, Lada Rumora i Stjepan Pepeljnjak. "Increased Permeability of the Blood-Brain Barrier Following Administration of Glyceryl Trinitrate in Common Carp (Cyprinus carpio L.)." Collegium antropologicum 32 - Supplement 1, br. 1 (2008): 99-103. https://hrcak.srce.hr/24561
Harvard
Kovačić, S., et al. (2008). 'Increased Permeability of the Blood-Brain Barrier Following Administration of Glyceryl Trinitrate in Common Carp (Cyprinus carpio L.)', Collegium antropologicum, 32 - Supplement 1(1), str. 99-103. Preuzeto s: https://hrcak.srce.hr/24561 (Datum pristupa: 25.02.2020.)
Vancouver
Kovačić S, Petrinec Z, Matašin Ž, Gjurčević E, Ivkić G, Lovrenčić-Huzjan A i sur. Increased Permeability of the Blood-Brain Barrier Following Administration of Glyceryl Trinitrate in Common Carp (Cyprinus carpio L.). Collegium antropologicum [Internet]. 2008 [pristupljeno 25.02.2020.];32 - Supplement 1(1):99-103. Dostupno na: https://hrcak.srce.hr/24561
IEEE
S. Kovačić, et al., "Increased Permeability of the Blood-Brain Barrier Following Administration of Glyceryl Trinitrate in Common Carp (Cyprinus carpio L.)", Collegium antropologicum, vol.32 - Supplement 1, br. 1, str. 99-103, 2008. [Online]. Dostupno na: https://hrcak.srce.hr/24561. [Citirano: 25.02.2020.]

Sažetak
Nitric oxide (NO) has been implicated in the pathogenesis of migraine and treatment with its exogenous donor glyceryl
trinitrate (GTN) represents widely accepted experimental »migraine model«. In this study, glyceryl trinitrate was
administered intraperitoneally to carps, serum nitrite and nitrate levels were determined, permeability of blood-brain
barrier was investigated, and histological changes of brain tissue were analyzed. Serum nitrite and nitrate levels displayed
characteristic biphasic pattern with moderate initial increase and maximal terminal increase, suggesting the
GTN-induced endogenous NO synthesis. Increased permeability of the blood-brain barrier in GTN-treated animals was
determined based on Evans blue capillary leakage into the brain tissue. Histological analysis revealed changes consistent
with vasodilatation and oedema. Our study strongly supports the importance of the NO role in the pathogenesis of
migraine attacks and increase in blood-brain barrier permeability during the attack. The study has also provided evidence
that this mechanism of action is conserved to the lower vertebrate.

Ključne riječi
migraine; glyceryl trinitrate; permeability; blood-brain barrier

Hrčak ID: 24561

URI
https://hrcak.srce.hr/24561

Posjeta: 892 *