hrcak mascot   Srce   HID

Original scientific paper
https://doi.org/10.2478/v10007-008-0014-3

Liposomi rivastigmina za isporuku u mozak intranazalnim putem

KARTHIK ARUMUGAM ; Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka-576 104, India
GANESA SUNDARARAJAN SUBRAMANIAN ; Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka-576 104, India
SURULIVEL RAJAN MALLAYASAMY ; Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka-576 104, India
RANJITH KUMAR AVERINENI ; Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka-576 104, India
MEKA SREENIVASA REDDY ; Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka-576 104, India
NAYANABHIRAMA UDUPA ; Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka-576 104, India

Fulltext: english, pdf (99 KB) pages 287-297 downloads: 1.487* cite
APA 6th Edition
ARUMUGAM, K., SUNDARARAJAN SUBRAMANIAN, G., RAJAN MALLAYASAMY, S., KUMAR AVERINENI, R., SREENIVASA REDDY, M. & UDUPA, N. (2008). A study of rivastigmine liposomes for delivery into the brain through the intranasal route. Acta Pharmaceutica, 58 (3), 287-297. https://doi.org/10.2478/v10007-008-0014-3
MLA 8th Edition
ARUMUGAM, KARTHIK, et al. "A study of rivastigmine liposomes for delivery into the brain through the intranasal route." Acta Pharmaceutica, vol. 58, no. 3, 2008, pp. 287-297. https://doi.org/10.2478/v10007-008-0014-3. Accessed 14 Aug. 2020.
Chicago 17th Edition
ARUMUGAM, KARTHIK, GANESA SUNDARARAJAN SUBRAMANIAN, SURULIVEL RAJAN MALLAYASAMY, RANJITH KUMAR AVERINENI, MEKA SREENIVASA REDDY and NAYANABHIRAMA UDUPA. "A study of rivastigmine liposomes for delivery into the brain through the intranasal route." Acta Pharmaceutica 58, no. 3 (2008): 287-297. https://doi.org/10.2478/v10007-008-0014-3
Harvard
ARUMUGAM, K., et al. (2008). 'A study of rivastigmine liposomes for delivery into the brain through the intranasal route', Acta Pharmaceutica, 58(3), pp. 287-297. https://doi.org/10.2478/v10007-008-0014-3
Vancouver
ARUMUGAM K, SUNDARARAJAN SUBRAMANIAN G, RAJAN MALLAYASAMY S, KUMAR AVERINENI R, SREENIVASA REDDY M, UDUPA N. A study of rivastigmine liposomes for delivery into the brain through the intranasal route. Acta Pharm. [Internet]. 2008 [cited 2020 August 14];58(3):287-297. https://doi.org/10.2478/v10007-008-0014-3
IEEE
K. ARUMUGAM, G. SUNDARARAJAN SUBRAMANIAN, S. RAJAN MALLAYASAMY, R. KUMAR AVERINENI, M. SREENIVASA REDDY and N. UDUPA, "A study of rivastigmine liposomes for delivery into the brain through the intranasal route", Acta Pharmaceutica, vol.58, no. 3, pp. 287-297, 2008. [Online]. https://doi.org/10.2478/v10007-008-0014-3

Abstracts
Glavni cilj rada je razvoj liposoma za intranazalnu primjenu za isporuku lijeka u mozak. U tu svrhu izabran je rivastigmin kao modelni lijek koji se upotrebljava u terapiji Alzheimerove bolesti. Liposomi su pripravljeni metodom hidratacije lipidnog sloja koristeći kolesterol i lecitin iz soje kao lipidne komponente. Praćena je koncentracija rivastigmina u mozgu i plazmi nakon intranazalne i peroralne primjene liposoma i slobodnog lijeka. S intranazalnim liposomima rivastigmina postignuta je značajno veća koncentracija lijeka u mozgu. Osim toga intranazalni liposomi imaju dulje vrijeme poluživota u mozgu. Intranazalna primjena liposoma rivastigmina mogla bi predstavljati novi pristup terapiji Alzheimerove bolesti.

Keywords
rivastigmin; liposomi; intranazalna primjena; isporuka lijeka u mozak; farmakokinetika

Hrčak ID: 25019

URI
https://hrcak.srce.hr/25019

[english]

Visits: 2.029 *