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Acta Pharmaceutica, Vol. 58 No. 3, 2008.

Kratko priopćenje
https://doi.org/10.2478/v10007-008-0015-2

Preparation and evaluation of an ispaghula based directly compressible matrixing agent for controlled release

ANITA N. LALWANI ; K. B. Institute of Pharmaceutical Education and Research, Gandhinagar-382 023, Gujarat, India
JOLLY R. PARIKH ; A. R. College of Pharmacy and G. H. Patel Institute of Pharmacy, Vallabh Vidyanagar-388 120, Gujarat, India

Puni tekst: engleski, pdf (72 KB) str. 309-316 preuzimanja: 608* citiraj
APA 6th Edition
N. LALWANI, A. i R. PARIKH, J. (2008). Preparation and evaluation of an ispaghula based directly compressible matrixing agent for controlled release. Acta Pharmaceutica, 58 (3), 309-316. https://doi.org/10.2478/v10007-008-0015-2
MLA 8th Edition
N. LALWANI, ANITA i JOLLY R. PARIKH. "Preparation and evaluation of an ispaghula based directly compressible matrixing agent for controlled release." Acta Pharmaceutica, vol. 58, br. 3, 2008, str. 309-316. https://doi.org/10.2478/v10007-008-0015-2. Citirano 24.05.2019.
Chicago 17th Edition
N. LALWANI, ANITA i JOLLY R. PARIKH. "Preparation and evaluation of an ispaghula based directly compressible matrixing agent for controlled release." Acta Pharmaceutica 58, br. 3 (2008): 309-316. https://doi.org/10.2478/v10007-008-0015-2
Harvard
N. LALWANI, A., i R. PARIKH, J. (2008). 'Preparation and evaluation of an ispaghula based directly compressible matrixing agent for controlled release', Acta Pharmaceutica, 58(3), str. 309-316. doi: https://doi.org/10.2478/v10007-008-0015-2
Vancouver
N. LALWANI A, R. PARIKH J. Preparation and evaluation of an ispaghula based directly compressible matrixing agent for controlled release. Acta Pharm. [Internet]. 2008 [pristupljeno 24.05.2019.];58(3):309-316. doi: https://doi.org/10.2478/v10007-008-0015-2
IEEE
A. N. LALWANI i J. R. PARIKH, "Preparation and evaluation of an ispaghula based directly compressible matrixing agent for controlled release", Acta Pharmaceutica, vol.58, br. 3, str. 309-316, 2008. [Online]. doi: https://doi.org/10.2478/v10007-008-0015-2

Sažetak
The objective of the present investigation was to prepare and evaluate an ispaghula husk based directly compressible (DC) adjuvant that can be used as matrixing agent using an agglomeration technique. Addition of hydroxylpropyl methylcellulose was found necessary to improve cohesion. Lactose (X1), calcium hydrogen phosphate diydrate (X2) and Avicel PH101 (X3), used along with ispaghula in preparation of agglomerates, were selected as three independent variables in a simplex lattice design affecting compressional and dissolution characteristics of the drug from the DC adjuvant. The agglomerates were evaluated for their flow properties. Tablets were prepared using 70% agglomerates and 30% acetaminophen, a poorly compressible drug, and were subjected to the in vitro drug release study. Amounts of the drug released at the end of 60 min (Y60), 300 min (Y300) and 480 min (Y480) were selected as dependent variables in a simplex lattice design. Batch IH05 that contained lactose and calcium hydrogen phosphate dihydrate in a 1:2 ratio could control the release for 12 hours and thus form the basis for twice-a-day dosing.

Ključne riječi
simplex lattice design; ispaghula husk; directly compressible; matrixing agent; similarity factor

Hrčak ID: 25022

URI
https://hrcak.srce.hr/25022

[hrvatski]

Posjeta: 851 *