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Original scientific paper

pH, Titratable Acidity and Total Soluble Solid Content of Pediatric Antitussive Medicines

Alessandro Leite Cavalcanti ; Department of Paediatric Dentistry, School of Dentistry, State University of Paraiba, Campina Grande, PB, Brazil
Ligia Virgilio Fernandes ; undergraduate student, Department of Paediatric Dentistry, School of Dentistry, State University of Paraiba, Campina Grande, PB, Brazil
Ariel Siqueira Barbosa ; undergraduate student, Department of Paediatric Dentistry, School of Dentistry, State University of Paraiba, Campina Grande, PB, Brazil
Fernando Fernandes Vieira ; Department of Analytical Chemistry, School of Chemistry, State University of Paraiba, Campina Grande, PB, Brazil

Fulltext: english, pdf (122 KB) pages 164-170 downloads: 555* cite
APA 6th Edition
Cavalcanti, A.L., Fernandes, L.V., Barbosa, A.S. & Vieira, F.F. (2008). pH, Titratable Acidity and Total Soluble Solid Content of Pediatric Antitussive Medicines. Acta stomatologica Croatica, 42 (2), 164-170. Retrieved from https://hrcak.srce.hr/25870
MLA 8th Edition
Cavalcanti, Alessandro Leite, et al. "pH, Titratable Acidity and Total Soluble Solid Content of Pediatric Antitussive Medicines." Acta stomatologica Croatica, vol. 42, no. 2, 2008, pp. 164-170. https://hrcak.srce.hr/25870. Accessed 17 Jun. 2021.
Chicago 17th Edition
Cavalcanti, Alessandro Leite, Ligia Virgilio Fernandes, Ariel Siqueira Barbosa and Fernando Fernandes Vieira. "pH, Titratable Acidity and Total Soluble Solid Content of Pediatric Antitussive Medicines." Acta stomatologica Croatica 42, no. 2 (2008): 164-170. https://hrcak.srce.hr/25870
Harvard
Cavalcanti, A.L., et al. (2008). 'pH, Titratable Acidity and Total Soluble Solid Content of Pediatric Antitussive Medicines', Acta stomatologica Croatica, 42(2), pp. 164-170. Available at: https://hrcak.srce.hr/25870 (Accessed 17 June 2021)
Vancouver
Cavalcanti AL, Fernandes LV, Barbosa AS, Vieira FF. pH, Titratable Acidity and Total Soluble Solid Content of Pediatric Antitussive Medicines. Acta stomatologica Croatica [Internet]. 2008 [cited 2021 June 17];42(2):164-170. Available from: https://hrcak.srce.hr/25870
IEEE
A.L. Cavalcanti, L.V. Fernandes, A.S. Barbosa and F.F. Vieira, "pH, Titratable Acidity and Total Soluble Solid Content of Pediatric Antitussive Medicines", Acta stomatologica Croatica, vol.42, no. 2, pp. 164-170, 2008. [Online]. Available: https://hrcak.srce.hr/25870. [Accessed: 17 June 2021]
Fulltext: croatian, pdf (122 KB) pages 164-170 downloads: 463* cite
APA 6th Edition
Cavalcanti, A.L., Fernandes, L.V., Barbosa, A.S. & Vieira, F.F. (2008). Vrijednost pH-a, kiselost titracije i ukupan udjel čvrste topljive tvari u pedijatrijskim lijekovima protiv kašlja. Acta stomatologica Croatica, 42 (2), 164-170. Retrieved from https://hrcak.srce.hr/25870
MLA 8th Edition
Cavalcanti, Alessandro Leite, et al. "Vrijednost pH-a, kiselost titracije i ukupan udjel čvrste topljive tvari u pedijatrijskim lijekovima protiv kašlja." Acta stomatologica Croatica, vol. 42, no. 2, 2008, pp. 164-170. https://hrcak.srce.hr/25870. Accessed 17 Jun. 2021.
Chicago 17th Edition
Cavalcanti, Alessandro Leite, Ligia Virgilio Fernandes, Ariel Siqueira Barbosa and Fernando Fernandes Vieira. "Vrijednost pH-a, kiselost titracije i ukupan udjel čvrste topljive tvari u pedijatrijskim lijekovima protiv kašlja." Acta stomatologica Croatica 42, no. 2 (2008): 164-170. https://hrcak.srce.hr/25870
Harvard
Cavalcanti, A.L., et al. (2008). 'Vrijednost pH-a, kiselost titracije i ukupan udjel čvrste topljive tvari u pedijatrijskim lijekovima protiv kašlja', Acta stomatologica Croatica, 42(2), pp. 164-170. Available at: https://hrcak.srce.hr/25870 (Accessed 17 June 2021)
Vancouver
Cavalcanti AL, Fernandes LV, Barbosa AS, Vieira FF. Vrijednost pH-a, kiselost titracije i ukupan udjel čvrste topljive tvari u pedijatrijskim lijekovima protiv kašlja. Acta stomatologica Croatica [Internet]. 2008 [cited 2021 June 17];42(2):164-170. Available from: https://hrcak.srce.hr/25870
IEEE
A.L. Cavalcanti, L.V. Fernandes, A.S. Barbosa and F.F. Vieira, "Vrijednost pH-a, kiselost titracije i ukupan udjel čvrste topljive tvari u pedijatrijskim lijekovima protiv kašlja", Acta stomatologica Croatica, vol.42, no. 2, pp. 164-170, 2008. [Online]. Available: https://hrcak.srce.hr/25870. [Accessed: 17 June 2021]

Abstracts
Objectives: This in vitro experimental study evaluated the endogenous pH, titratable acidity and total soluble solids content (TSSC) of pediatric antitussive medicines presented as syrups. Materials and Methods: Seven medicines were evaluated by a random experiment with 3 repetitions for each sample. pH analysis was performed by potentiometry and buffering capacity was assessed by dilution of each medicine. Increments of 0.1 N KOH were titrated until neutrality was reached. TSSC readings were performed by Brix refractometry using the Abbé refractometer. Results: pH values ranged from 2.65 (Mucolin®) to 6.56 (Fluimucil®) and four medicines showed pH below the critical value of 5.5. The titratable acidity values ranged from 0.061 (Fluimucil®) to 0.467 (Ambroxmel®). Fluimucil® presented the lowest TSSC content (4.33%) and Mucofan® presented the highest TSSC content (53.41%). Conclusions: Many pediatric antitussives showed pH below the critical value, high titratable values and high sugar concentration, which may increase their cariogenic and erosive potentials in case of inadequate administration of these products to children.

Keywords
Pharmaceutical Preparations; Sweetening Agents; Administration, Oral; Tooth Erosion; Dental Caries; Antitusive Agents

Hrčak ID: 25870

URI
https://hrcak.srce.hr/25870

[croatian]

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