Izvorni znanstveni članak
pH, Titratable Acidity and Total Soluble Solid Content of Pediatric Antitussive Medicines
Alessandro Leite Cavalcanti
; Zavod za dječju stomatologiju, Stomatološki fakultet Sveučilišta Paraibe, Campina Grande, Brazil
Ligia Virgilio Fernandes
; student, Zavod za dječju stomatologiju, Stomatološki fakultet Sveučilišta Paraibe, Campina Grande, Brazil
Ariel Siqueira Barbosa
; student, Zavod za dječju stomatologiju, Stomatološki fakultet Sveučilišta Paraibe, Campina Grande, Brazil
Fernando Fernandes Vieira
; Zavod za analitičku kemiju, Kemijski fakultet Sveučilišta Paraibe, Campina Grande, Brazil
Sažetak
Objectives: This in vitro experimental study evaluated the endogenous pH, titratable acidity and total soluble solids content (TSSC) of pediatric antitussive medicines presented as syrups. Materials and Methods: Seven medicines were evaluated by a random experiment with 3 repetitions for each sample. pH analysis was performed by potentiometry and buffering capacity was assessed by dilution of each medicine. Increments of 0.1 N KOH were titrated until neutrality was reached. TSSC readings were performed by Brix refractometry using the Abbé refractometer. Results: pH values ranged from 2.65 (Mucolin®) to 6.56 (Fluimucil®) and four medicines showed pH below the critical value of 5.5. The titratable acidity values ranged from 0.061 (Fluimucil®) to 0.467 (Ambroxmel®). Fluimucil® presented the lowest TSSC content (4.33%) and Mucofan® presented the highest TSSC content (53.41%). Conclusions: Many pediatric antitussives showed pH below the critical value, high titratable values and high sugar concentration, which may increase their cariogenic and erosive potentials in case of inadequate administration of these products to children.
Ključne riječi
Pharmaceutical Preparations; Sweetening Agents; Administration, Oral; Tooth Erosion; Dental Caries; Antitusive Agents
Hrčak ID:
25870
URI
Datum izdavanja:
15.6.2008.
Posjeta: 2.670 *