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Acta Pharmaceutica, Vol. 58 No. 4, 2008.

Izvorni znanstveni članak
https://doi.org/10.2478/v10007-008-0021-4

Sinteza i farmakološko vrednovanje 2-supstituiranih-6-fenil-4,5-dihidropiridazin-3(2H)-ona kao snažnih srčanih stimulatora

DINESH KUMAR ; University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India
ROSALIA CARRON ; Departamento de Fisiología y Farmacología, Facultad d Farmacia, Campus "Miguel de Unamuno" E-37007 Salamanca, Spain
CARMEN DE LA CALLE ; Departamento de Fisiología y Farmacología, Facultad d Farmacia, Campus "Miguel de Unamuno" E-37007 Salamanca, Spain
DHARAM PAUL JINDAL ; University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India
RANJU BANSAL ; University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India

Puni tekst: engleski, pdf (99 KB) str. 393-405 preuzimanja: 699* citiraj
APA 6th Edition
KUMAR, D., CARRON, R., DE LA CALLE, C., PAUL JINDAL, D. i BANSAL, R. (2008). Synthesis and evaluation of 2-substituted-6-phenyl-4,5-dihydropyridazin-3(2H)-ones as potent inodilators. Acta Pharmaceutica, 58 (4), 393-405. https://doi.org/10.2478/v10007-008-0021-4
MLA 8th Edition
KUMAR, DINESH, et al. "Synthesis and evaluation of 2-substituted-6-phenyl-4,5-dihydropyridazin-3(2H)-ones as potent inodilators." Acta Pharmaceutica, vol. 58, br. 4, 2008, str. 393-405. https://doi.org/10.2478/v10007-008-0021-4. Citirano 19.02.2019.
Chicago 17th Edition
KUMAR, DINESH, ROSALIA CARRON, CARMEN DE LA CALLE, DHARAM PAUL JINDAL i RANJU BANSAL. "Synthesis and evaluation of 2-substituted-6-phenyl-4,5-dihydropyridazin-3(2H)-ones as potent inodilators." Acta Pharmaceutica 58, br. 4 (2008): 393-405. https://doi.org/10.2478/v10007-008-0021-4
Harvard
KUMAR, D., et al. (2008). 'Synthesis and evaluation of 2-substituted-6-phenyl-4,5-dihydropyridazin-3(2H)-ones as potent inodilators', Acta Pharmaceutica, 58(4), str. 393-405. doi: https://doi.org/10.2478/v10007-008-0021-4
Vancouver
KUMAR D, CARRON R, DE LA CALLE C, PAUL JINDAL D, BANSAL R. Synthesis and evaluation of 2-substituted-6-phenyl-4,5-dihydropyridazin-3(2H)-ones as potent inodilators. Acta Pharm. [Internet]. 2008 [pristupljeno 19.02.2019.];58(4):393-405. doi: https://doi.org/10.2478/v10007-008-0021-4
IEEE
D. KUMAR, R. CARRON, C. DE LA CALLE, D. PAUL JINDAL i R. BANSAL, "Synthesis and evaluation of 2-substituted-6-phenyl-4,5-dihydropyridazin-3(2H)-ones as potent inodilators", Acta Pharmaceutica, vol.58, br. 4, str. 393-405, 2008. [Online]. doi: https://doi.org/10.2478/v10007-008-0021-4

Sažetak
U radu je opisana sinteza i framakološko vrednovanje 2-supstituiranih-6-(4-acilaminofenil)-4,5-dihidropiridazin-3(2H)-ona kao snažnih srčanih stimulatora. Spojevi 2-4 i 7-11 sintetizirani su Friedel-Craftsovim acilaranjem odgovarajućeg anilida s anhidridom jantarne ili anhidridom metiljantarne kiseline te ciklizacijom intermedijarnih keto kiselina s različitim derivatima hidrazina. Kardiotonično djelovanje novosintetiziranih derivata piridazinona ispitano je na izoliranim atrijima štakora, a vazodilatirajuće djelovanje na silaznim torakalnim prstenima aorte prethodno kontrahiranim fenilefrinom (106 mol L1). 6-(4-Metansulfonamidofenil)-2-fenil-4,5-dihidropiridazin-3(2H)-on (7) pokazao je značajno stimulativno i vazodilatirajuće djelovanje u nanomolarnim koncentracijama (IC50 = 0,08  0,01 μmol L1).

Ključne riječi
piridazinoni; anilidi; derivati hidrazina; kardiotonično djelovanje; vazodilatacijsko djelovanje

Hrčak ID: 26482

URI
https://hrcak.srce.hr/26482

[engleski]

Posjeta: 930 *