hrcak mascot   Srce   HID

Arhiv za higijenu rada i toksikologiju, Vol. 59 No. 3, 2008.

Izvorni znanstveni članak
https://doi.org/10.2478/10004-1254-59-2008-1873

Acute Toxicity and Cholinesterase Inhibition in Chicks Dosed Orally with Organophosphate Insecticides

Fouad K. Mohammad ; Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine,University of Mosul, Mosul, Iraq
Yasser M. Al-Badrany ; Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine,University of Mosul, Mosul, Iraq
Mohammed M. Al-Jobory ; Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine,University of Mosul, Mosul, Iraq

Puni tekst: engleski, pdf (107 KB) str. 145-151 preuzimanja: 1.277* citiraj
APA 6th Edition
Mohammad, F.K., Al-Badrany, Y.M. i Al-Jobory, M.M. (2008). Acute Toxicity and Cholinesterase Inhibition in Chicks Dosed Orally with Organophosphate Insecticides. Arhiv za higijenu rada i toksikologiju, 59 (3), 145-151. https://doi.org/10.2478/10004-1254-59-2008-1873
MLA 8th Edition
Mohammad, Fouad K., et al. "Acute Toxicity and Cholinesterase Inhibition in Chicks Dosed Orally with Organophosphate Insecticides." Arhiv za higijenu rada i toksikologiju, vol. 59, br. 3, 2008, str. 145-151. https://doi.org/10.2478/10004-1254-59-2008-1873. Citirano 17.02.2019.
Chicago 17th Edition
Mohammad, Fouad K., Yasser M. Al-Badrany i Mohammed M. Al-Jobory. "Acute Toxicity and Cholinesterase Inhibition in Chicks Dosed Orally with Organophosphate Insecticides." Arhiv za higijenu rada i toksikologiju 59, br. 3 (2008): 145-151. https://doi.org/10.2478/10004-1254-59-2008-1873
Harvard
Mohammad, F.K., Al-Badrany, Y.M., i Al-Jobory, M.M. (2008). 'Acute Toxicity and Cholinesterase Inhibition in Chicks Dosed Orally with Organophosphate Insecticides', Arhiv za higijenu rada i toksikologiju, 59(3), str. 145-151. doi: https://doi.org/10.2478/10004-1254-59-2008-1873
Vancouver
Mohammad FK, Al-Badrany YM, Al-Jobory MM. Acute Toxicity and Cholinesterase Inhibition in Chicks Dosed Orally with Organophosphate Insecticides. Arh Hig Rada Toksikol. [Internet]. 2008 [pristupljeno 17.02.2019.];59(3):145-151. doi: https://doi.org/10.2478/10004-1254-59-2008-1873
IEEE
F.K. Mohammad, Y.M. Al-Badrany i M.M. Al-Jobory, "Acute Toxicity and Cholinesterase Inhibition in Chicks Dosed Orally with Organophosphate Insecticides", Arhiv za higijenu rada i toksikologiju, vol.59, br. 3, str. 145-151, 2008. [Online]. doi: https://doi.org/10.2478/10004-1254-59-2008-1873

Sažetak
Acute toxic effects of three commonly used insecticidal preparations of the organophosphates chlorpyrifos, diazinon, and dichlorvos were examined in mixed breed broiler chicks, and cholinesterase activity in plasma and brain were measured. The acute (24 h) oral median lethal doses (LD50) of chlorpyrifos, diazinon, and dichlorvos were 10.79 mg kg-1, 6.32 mg kg-1, and 6.30 mg kg-1, respectively, as determined by the up-and-down method in chicks. Signs of cholinergic toxicosis in the chicks appeared within two hours after dosing, and they included salivation, lacrimation, gasping, frequent defecation, drooping of wings, tremors, convulsions, and recumbency before death. Halving the oral LD50 of chlorpyrifos (5 mg kg-1), diazinon (3 mg kg-1), and dichlorvos (3 mg kg-1) caused immobility and wing drooping, but not the clinical signs of cholinergic toxicity. However, at full LD50 doses of these insecticides, chicks showed clinical signs of cholinergic toxicity similar to those seen in the LD50 experiments. Two out of six chicks died within two hours after treatment with LD50 doses of chlorpyrifos and dichlorvos, whereas LD50 dosing with diazinon caused death in three out of six chicks. Compared to control values, the insecticides reduced plasma and whole brain cholinesterase activities by 29 % to 84 % and 18 % to 77 %, respectively, depending on the dose. The decrease in plasma cholinesterase correlated well (r = 0.82) with that of the brain. These data suggest that organophosphate insecticides administered orally at LD50 doses induce clinical signs of cholinergic poisoning and concurrently reduce brain and plasma cholinesterase activities in chicks.

Ključne riječi
anticholinesterases; chlorpyrifos; cholinergic toxicity; diazinon; dichlorvos; LD50

Hrčak ID: 26582

URI
https://hrcak.srce.hr/26582

[hrvatski]

Posjeta: 1.991 *