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Non-linear optimization of parameters in Michaelis-Menten kinetics

Željko Jeričević
Željko Kušter

Puni tekst: engleski, pdf (141 KB) str. 519-523 preuzimanja: 3.014* citiraj
APA 6th Edition
Jeričević, Ž. i Kušter, Ž. (2005). Non-linear optimization of parameters in Michaelis-Menten kinetics. Croatica Chemica Acta, 78 (4), 519-523. Preuzeto s https://hrcak.srce.hr/2539
MLA 8th Edition
Jeričević, Željko i Željko Kušter. "Non-linear optimization of parameters in Michaelis-Menten kinetics." Croatica Chemica Acta, vol. 78, br. 4, 2005, str. 519-523. https://hrcak.srce.hr/2539. Citirano 08.03.2021.
Chicago 17th Edition
Jeričević, Željko i Željko Kušter. "Non-linear optimization of parameters in Michaelis-Menten kinetics." Croatica Chemica Acta 78, br. 4 (2005): 519-523. https://hrcak.srce.hr/2539
Harvard
Jeričević, Ž., i Kušter, Ž. (2005). 'Non-linear optimization of parameters in Michaelis-Menten kinetics', Croatica Chemica Acta, 78(4), str. 519-523. Preuzeto s: https://hrcak.srce.hr/2539 (Datum pristupa: 08.03.2021.)
Vancouver
Jeričević Ž, Kušter Ž. Non-linear optimization of parameters in Michaelis-Menten kinetics. Croatica Chemica Acta [Internet]. 2005 [pristupljeno 08.03.2021.];78(4):519-523. Dostupno na: https://hrcak.srce.hr/2539
IEEE
Ž. Jeričević i Ž. Kušter, "Non-linear optimization of parameters in Michaelis-Menten kinetics", Croatica Chemica Acta, vol.78, br. 4, str. 519-523, 2005. [Online]. Dostupno na: https://hrcak.srce.hr/2539. [Citirano: 08.03.2021.]

Sažetak
A novel least squares optimization of parameters in Michaelis-Menten enzyme kinetics has been developed. The method is based on elimination of linear parameter from so called normal equations which transforms a non-linear, two-parameter optimization problem into one of finding a root of non-linear equation. The algorithm is simple and has guaranteed convergence with initial guess of zero for KM. Data set from literature is used to illustrate feasibility of the method and accuracy of the solution in comparison with linearization methods and general optimization technique.

Ključne riječi
Michaelis-Menten enzyme kinetics; non-linear optimization; data processing; least squares

Hrčak ID: 2539

URI
https://hrcak.srce.hr/2539

[hrvatski]

Posjeta: 3.546 *