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https://doi.org/10.2478/v10007-008-0023-2

Development and in vitro evaluation of an acid buffering bioadhesive vaginal gel for mixed vaginal infections

FARHAN JALEES AHMAD ; Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, New Delhi-110062, India
MOHD AFTAB ALAM ; Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, New Delhi-110062, India
ZEENAT IQBAL KHAN ; Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, New Delhi-110062, India
ROOP KRISHEN KHAR ; Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, New Delhi-110062, India
MUSHIR ALI ; Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, New Delhi-110062, India

Puni tekst: engleski, pdf (97 KB) str. 407-419 preuzimanja: 1.109* citiraj
APA 6th Edition
AHMAD, F.J., ALAM, M.A., KHAN, Z.I., KHAR, R.K. i ALI, M. (2008). Development and in vitro evaluation of an acid buffering bioadhesive vaginal gel for mixed vaginal infections. Acta Pharmaceutica, 58 (4), 407-419. https://doi.org/10.2478/v10007-008-0023-2
MLA 8th Edition
AHMAD, FARHAN JALEES, et al. "Development and in vitro evaluation of an acid buffering bioadhesive vaginal gel for mixed vaginal infections." Acta Pharmaceutica, vol. 58, br. 4, 2008, str. 407-419. https://doi.org/10.2478/v10007-008-0023-2. Citirano 27.06.2019.
Chicago 17th Edition
AHMAD, FARHAN JALEES, MOHD AFTAB ALAM, ZEENAT IQBAL KHAN, ROOP KRISHEN KHAR i MUSHIR ALI. "Development and in vitro evaluation of an acid buffering bioadhesive vaginal gel for mixed vaginal infections." Acta Pharmaceutica 58, br. 4 (2008): 407-419. https://doi.org/10.2478/v10007-008-0023-2
Harvard
AHMAD, F.J., et al. (2008). 'Development and in vitro evaluation of an acid buffering bioadhesive vaginal gel for mixed vaginal infections', Acta Pharmaceutica, 58(4), str. 407-419. doi: https://doi.org/10.2478/v10007-008-0023-2
Vancouver
AHMAD FJ, ALAM MA, KHAN ZI, KHAR RK, ALI M. Development and in vitro evaluation of an acid buffering bioadhesive vaginal gel for mixed vaginal infections. Acta Pharm. [Internet]. 2008 [pristupljeno 27.06.2019.];58(4):407-419. doi: https://doi.org/10.2478/v10007-008-0023-2
IEEE
F.J. AHMAD, M.A. ALAM, Z.I. KHAN, R.K. KHAR i M. ALI, "Development and in vitro evaluation of an acid buffering bioadhesive vaginal gel for mixed vaginal infections", Acta Pharmaceutica, vol.58, br. 4, str. 407-419, 2008. [Online]. doi: https://doi.org/10.2478/v10007-008-0023-2

Sažetak
An acid buffering bioadhesive vaginal (ABBV) gel was developed for the treatment of mixed vaginal infections. Different bioadhesive polymers were evaluated on the basis of their bioadhesive strength, stability and drug release properties. Bioadhesion and release studies showed that guar gum, xanthan gum and hydroxypropylmethylcellulose K4M formed a good combination of bioadhesive polymers to develop the ABBV gel. Mono sodium citrate was used as an acid buffering agent to provide acidic pH (4.4). The drugs clotrimazole (antifungal) and metronidazole (antiprotozoal as well as antibacterial) were used in the formulation along with Lactobacillus spores to treat mixed vaginal infections. The ex vivo retention study showed that the bioadhesive polymers hold the gel for 12-13 hours inside the vaginal tube. Results of the in vitro antimicrobial study indicated that the ABBV gel had better antimicrobial action than the commercial intravaginal drug delivery systems and retention was prolonged in an ex vivo retention experiment.

Ključne riječi
acid buffering gel; vaginal bioadhesion; bioadhesive polymers; mixed vaginal infections

Hrčak ID: 26775

URI
https://hrcak.srce.hr/26775

[hrvatski]

Posjeta: 1.713 *