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Kratko priopćenje
https://doi.org/10.2478/v10007-008-0025-0

Sinteza 2-(1H-indol-3-il)acetil-N-(supstituiranih fenil)hidrazinkarbotioamida i srodnih heterocikličkih spojeva te procjena njihovog antikonvulzivnog djelovanja i toksičnosti

NADEEM SIDDIQUI ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi-110062, India
M. SHAMSHER ALAM ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi-110062, India
WAQUAR AHSAN ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi-110062, India

Puni tekst: engleski, pdf (79 KB) str. 445-454 preuzimanja: 684* citiraj
APA 6th Edition
SIDDIQUI, N., ALAM, M.S. i AHSAN, W. (2008). Synthesis, anticonvulsant and toxicity evaluation of 2-(1H-indol-3-ylacetyl)-N-(substituted phenyl)hydrazinecarbothioamides and their related heterocyclic derivatives. Acta Pharmaceutica, 58 (4), 445-454. https://doi.org/10.2478/v10007-008-0025-0
MLA 8th Edition
SIDDIQUI, NADEEM, et al. "Synthesis, anticonvulsant and toxicity evaluation of 2-(1H-indol-3-ylacetyl)-N-(substituted phenyl)hydrazinecarbothioamides and their related heterocyclic derivatives." Acta Pharmaceutica, vol. 58, br. 4, 2008, str. 445-454. https://doi.org/10.2478/v10007-008-0025-0. Citirano 27.06.2019.
Chicago 17th Edition
SIDDIQUI, NADEEM, M. SHAMSHER ALAM i WAQUAR AHSAN. "Synthesis, anticonvulsant and toxicity evaluation of 2-(1H-indol-3-ylacetyl)-N-(substituted phenyl)hydrazinecarbothioamides and their related heterocyclic derivatives." Acta Pharmaceutica 58, br. 4 (2008): 445-454. https://doi.org/10.2478/v10007-008-0025-0
Harvard
SIDDIQUI, N., ALAM, M.S., i AHSAN, W. (2008). 'Synthesis, anticonvulsant and toxicity evaluation of 2-(1H-indol-3-ylacetyl)-N-(substituted phenyl)hydrazinecarbothioamides and their related heterocyclic derivatives', Acta Pharmaceutica, 58(4), str. 445-454. doi: https://doi.org/10.2478/v10007-008-0025-0
Vancouver
SIDDIQUI N, ALAM MS, AHSAN W. Synthesis, anticonvulsant and toxicity evaluation of 2-(1H-indol-3-ylacetyl)-N-(substituted phenyl)hydrazinecarbothioamides and their related heterocyclic derivatives. Acta Pharm. [Internet]. 2008 [pristupljeno 27.06.2019.];58(4):445-454. doi: https://doi.org/10.2478/v10007-008-0025-0
IEEE
N. SIDDIQUI, M.S. ALAM i W. AHSAN, "Synthesis, anticonvulsant and toxicity evaluation of 2-(1H-indol-3-ylacetyl)-N-(substituted phenyl)hydrazinecarbothioamides and their related heterocyclic derivatives", Acta Pharmaceutica, vol.58, br. 4, str. 445-454, 2008. [Online]. doi: https://doi.org/10.2478/v10007-008-0025-0

Sažetak
Reakcijom 2-(1H-indol-3-il)acetil-N-(supstituiranih fenil)hidrazinkarbotioamida (3a-g) s odgovarajućim reaktantom sintetizirana je serija novih 5-(1H-indol-3-il)metil-4-(supstituiranih aril)-2,4-dihidro-3H-1,2,4-triazol-3-tiona (4a-g), 5-(1H-indol-3-yl)metil-N-(supstituiranih aril)-1,3,4-oksadiazol-2-amina (5a-g) i 5-(1H-indol-3-il)metil-N-(supstituiranih aril)-1,3,4-tiadiazol-2-amina (6a-g). Ispitano je antikonvulzivno djelovanje sintetiziranih spojeva na MES modelu i uspoređeno s djelovanjem fenitoin natrija i karbamazepina. Spojevi 4b, 4e, 4f, 5b, 5d, 5g, 6b, 6d i 6e pokazali su MES djelovanje usporedivo s djelovanjem fenitoina i karbamazepina nakon 0,5 h, dok je spoj 5b nakon 4 sata imao snažnije djelovanje od karbamazepina. Osim toga, spojevi 4a, 4c, 4d, 5a, 5c, 5e, 5f, 6f i 6g su manje neurotoksični od fenitoina.

Ključne riječi
indoli; triazoli; tiadiazoli; oksadiazoli; antikonvulzivi; neurotoksičnost

Hrčak ID: 26799

URI
https://hrcak.srce.hr/26799

[engleski]

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